Results 41 to 50 of about 45,704 (289)

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

“If it’s a broad spectrum, it can shoot better”: inappropriate antibiotic prescribing in Cambodia

Antimicrobial Resistance and Infection Control, 2016
Background Cambodia is affected by antibiotic resistance but interventions to reduce the level of resistance require knowledge of the phenomena that lead to inappropriate prescribing.
Chhorvoin Om, Frances Daily, Erika Vlieghe, James C. McLaughlin, Mary-Louise McLaws   +4 more
doaj   +1 more source

Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, EarlyView.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W. Cannon, Brian C. Sauer, Jorge Rojas, Gregory J. Stoddard, Gary A. Kunkel, Jessica A. Walsh, Bryant R. England, Joshua F. Baker, Tawnie J. Braaten   +9 more
wiley   +1 more source

Evaluation of Potentially Inappropriate Drug Use in Older Adult Outpatients Using the Turkish Inappropriate Medication Use in the Elderly Criteria in Kütahya Province, Turkey

İstanbul Medical Journal, 2023
Introduction:The population aged 65 years and older has the highest rates of drug use and is more sensitive to drug effects. Appropriate medication use among older adults is associated with poor clinical outcomes.
Ertaç Berker, Türkan Paşalı Kilit, Filiz Özyiğit   +2 more
doaj   +1 more source

Inappropriate dosing of direct oral anticoagulants: findings from a clinical vignette study and physician survey

Journal of Market Access & Health Policy, 2023
Objective Direct oral anticoagulants (DOACs) are first-line therapy for stroke prevention for 1.4 million atrial fibrillation (AF) patients in the UK. However, the rates of DOAC dosing below evidence-based recommendations are estimated between 9% and 22%.
Ahmet Fuat, Emmanuel Ako, David Hargroves, Douglas Holden, Amrit Caleyachetty, Matthew Carter, James Harris, Carol Roberts, Nnanyelu Nzeakor, Burcu Vardar, Helen Williams   +10 more
doaj   +1 more source

Predictors of Inappropriate Antibiotic Prescribing in Australian General Practice / Primary Care Settings [PDF]

, 2023
The objective of this thesis was to identify Guideline non-conforming prescribing of systemic antibiotics in Western Australian general practice for initial presentations of acute upper respiratory tract infection and urinary tract infection.
Harrison, Amy Elizabeth
core  

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source

Tackling potentially inappropriate prescriptions in older adults: development of deprescribing criteria by consensus from experts in Colombia, Argentina, and Spain

BMC Geriatrics, 2023
Background Potentially inappropriate medication use is prevalent among older adults in primary care, leading to increased morbidity, adverse drug reactions, hospitalizations, and mortality.
Roxana De las salas, Claudia Vaca-González, Javier Eslava-Schmalbach, Catalina Torres-Espinosa, Albert Figueras   +4 more
doaj   +1 more source

Explicit criteria for potentially inappropriate medications to reduce the risk of adverse drug reactions in elderly people: from Beers to STOPP/START criteria

, 2012
Balanced and safe prescribing is difficult to achieve in frail older adults with multiple comorbid diseases. For this reason, great efforts have been made in the search for interventions to improve efficacy, safety and appropriateness of prescriptions in
Onder, Graziano
core   +1 more source

Minimal Important Change and Minimal Clinically Important Difference in Pain and Function With Exercise in Hip Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to estimate the minimal important change (MIC) and minimal clinically important difference (MCID) for pain and physical function in individuals with hip osteoarthritis (OA) following a physiotherapist‐guided exercise intervention.
Yareni Guerrero, Fiona Dobson, Venkatesha Venkatesha, Kim Allison, Gabrielle Knox, Libby Spiers, Travis Haber, David J Hunter, Michelle Hall   +8 more
wiley   +1 more source