GSK3 inhibitor enhances gemtuzumab ozogamicin‐induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance [PDF]
eJHaem, 2023 In acute myeloid leukemia (AML), the heterogeneity of genetic and epigenetic characteristics makes treatment difficult. The prognosis for AML is therefore poor, and there is an urgent need for new treatments for this condition. Gemtuzumab ozogamicin (GO),
Aki Inase +17 more
doaj +3 more sources
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality.
Achinto Saha +9 more
doaj +2 more sources
Probing the Hybrid σ/π-Holes in sp<sup>2</sup>-Hybridized Chalcogen Bond Donors and their Complexes with Ammonia. [PDF]
ChemphyschemA double‐bonded chalcogen bond donor exhibits both a σ‐hole and a π‐hole on the same atom. These unique σ/π‐holes can be tuned based on molecular composition to be directional or semidirectional depending on the donor–acceptor bonding configuration, which differs from the behavior of other electropositive holes.
French KA +3 more
europepmc +2 more sources
SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer [PDF]
Antioxidants, 2022 SLC7A11 is a cell transmembrane protein composing the light chain of system xc−, transporting extracellular cystine into cells for cysteine production and GSH biosynthesis.
Jaewang Lee, Jong-Lyel Roh
doaj +2 more sources
Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer [PDF]
Redox BiologyMetabolic reprogramming is a hallmark of human cancer, and cancer-specific metabolism provides opportunities for cancer diagnosis, prognosis, and treatment.
Zhang Lin +12 more
doaj +2 more sources
Thoracic Cancer, 2022 Background A standard treatment regimen for advanced non‐small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) has not been established since most clinical trials exclude such patients because of the high risk of acute exacerbation
Hiroyuki Sakashita +18 more
doaj +2 more sources
Protección del medio ambiente y Ley 16.811 de creación de INASE
Revista de la Facultad de Derecho, 2005 Conferencia brindada el 9 de junio de 1997 en el. Simposio de Armonización del Derecho Ambiental en el Mundo¡ El presente trabajo se publica concomitantemente en el Jño 1998 en la Revista de la Facultad de Derecho No.
Gastón Casaux
doaj +2 more sources
Cerullo, Luca. Cuerpos inasibles y almas huidizas. El personaje en Carmen Laforet [PDF]
Anales de Literatura Española, 2021 Reseña de: Cerullo, Luca. Cuerpos inasibles y almas huidizas. El personaje en Carmen Laforet.
openaire +4 more sources
Inased (inhaled sedation in ICU) trial protocol: a multicentre randomised open-label trial [PDF]
BMJ Open, 2021 IntroductionThe use of sedation in intensive care units (ICUs) is necessary and ubiquitous. The impact of sedation strategy on outcome, particularly when delivered early after initiation of mechanical ventilation, is unknown. Evidence is increasing that volatile anaesthetic agents could be associated with better outcome.
Pierre Bailly +10 more
openaire +4 more sources
Descripción para el registro de la primera variedad tipo Desi TUC 450 desarrollada por la Estación Experimental Agroindustrial Obispo Colombres [PDF]
Revista Industrial y Agrícola de Tucumán, 2021 El Proyecto Legumbres Secas de la Estación Experimental Agroindustrial Obispo Colombres ha desarrollado una nueva variedad de garbanzo (Cicer arietinum L.) tipo Desi, denominada TUC 450, primera en este acervo genético para registrar en la Argentina. Con
Clara M. Espeche +5 more
doaj