Cyst(e)inase–Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer [PDF]
Molecular Cancer Therapeutics, 2022 Abstract Renal cell carcinomas associated with hereditary leiomyomatosis and renal cell cancer (HLRCC) are notoriously aggressive and represent the leading cause of death among patients with HLRCC. To date, a safe and effective standardized therapy for this tumor type is lacking.
Baris Kerimoglu +2 more
exaly +4 more sources
GSK3 inhibitor enhances gemtuzumab ozogamicin‐induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance [PDF]
eJHaem, 2023 In acute myeloid leukemia (AML), the heterogeneity of genetic and epigenetic characteristics makes treatment difficult. The prognosis for AML is therefore poor, and there is an urgent need for new treatments for this condition. Gemtuzumab ozogamicin (GO),
Aki Inase +17 more
doaj +3 more sources
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality.
Achinto Saha +9 more
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Systemic cyst(e)inase administration induces ferroptosis and synergizes with temozolomide in glioblastoma. [PDF]
iScienceGlioblastoma (GBM), an aggressive primary brain cancer, exhibits therapeutic resistance because of tumor heterogeneity and highly plastic glioma stem cells (GSCs). This study targets the metabolic vulnerability of GSCs to cysteine depletion using Cyst(e)inase, a cysteine-degrading enzyme.
Ahmad F +11 more
europepmc +3 more sources
Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer [PDF]
Redox BiologyMetabolic reprogramming is a hallmark of human cancer, and cancer-specific metabolism provides opportunities for cancer diagnosis, prognosis, and treatment.
Zhang Lin +12 more
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Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth [PDF]
Nature Medicine, 2016 Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than do non-malignant cells because of genetic alterations and abnormal growth; as a result, maintenance of the antioxidant glutathione (GSH) is essential for their survival and proliferation.
Peng Huang, Everett Stone, Jinyun Liu
exaly +3 more sources
Protección del medio ambiente y Ley 16.811 de creación de INASE
Revista de la Facultad de Derecho, 2005 Conferencia brindada el 9 de junio de 1997 en el. Simposio de Armonización del Derecho Ambiental en el Mundo¡ El presente trabajo se publica concomitantemente en el Jño 1998 en la Revista de la Facultad de Derecho No.
Gastón Casaux
doaj +2 more sources
Inased (inhaled sedation in ICU) trial protocol: a multicentre randomised open-label trial [PDF]
BMJ Open, 2021 Introduction The use of sedation in intensive care units (ICUs) is necessary and ubiquitous. The impact of sedation strategy on outcome, particularly when delivered early after initiation of mechanical ventilation, is unknown.
Pierre Bailly +10 more
openaire +4 more sources
Descripción para el registro de la primera variedad tipo Desi TUC 450 desarrollada por la Estación Experimental Agroindustrial Obispo Colombres [PDF]
Revista Industrial y Agrícola de Tucumán, 2021 El Proyecto Legumbres Secas de la Estación Experimental Agroindustrial Obispo Colombres ha desarrollado una nueva variedad de garbanzo (Cicer arietinum L.) tipo Desi, denominada TUC 450, primera en este acervo genético para registrar en la Argentina. Con
Clara M. Espeche +5 more
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