Results 131 to 140 of about 145,125 (343)

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

Some Philosophical Remarks on Educating Genuine Leaders [PDF]

, 2012
The author intends to make an appeal for paying closer attention to human nature in educating genuine leaders. His philosophical approach embraces following topics: (1) whether leaders are born with talents and traits that allow, or even cause, them to ...
Tarasiewicz, Pawel
core  

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Immediate adverse events to intravenous immunoglobulin in pediatric patients with inborn errors of immunity: A longitudinal study with a pre-infusion protocol

, 2022
Thales Silva Antunes, Karina Mescouto de Melo, Cláudia França Cavalcante Valente, Fabíola Scancetti Tavares   +3 more
openalex   +1 more source

Screening for inborn errors of metabolism using untargeted metabolomics and out-of-batch controls [PDF]

, 2020
Michiel Bongaerts, Ramon Bonte, Serwet Demirdas, Ed H. Jacobs, Esmée Oussoren, Ans T. van der Ploeg, Margreet A.E.M. Wagenmakers, Robert M.W. Hofstra, Henk J. Blom, Marcel J.T. Reinders, George J. G. Ruijter   +10 more
openalex   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Evidence-based Decision-making on Management of Arteriovenous Malformation of Face

Indian Journal of Vascular and Endovascular Surgery
Arteriovenous malformations (AVMs) are uncommon inborn vascular anomaly, making for about 1.5% of all vascular aberrations. Remarkably, approximately half of AVM cases manifest in the mouth cavity and faciomaxillary region.
Navin Shah, Rishabh N Shah, Anurag Jain, Nikhil Angre   +3 more
doaj  

Evidence of epigenetic landscape shifts in mucopolysaccharidosis IIIB and IVA

Scientific Reports
Lysosomal storage diseases (LSDs) are a group of monogenic diseases characterized by mutations in genes coding for proteins associated with the lysosomal function.
Viviana Vargas-López, Luisa F. Prada, Carlos J. Alméciga-Díaz   +2 more
doaj   +1 more source

The Integrity of Thinking [PDF]

, 2018
When we look at our political landscape today, I wonder where has our integrity gone? Teachers want to know how to explain (if that’s the right word) the language and behavior of the current American president to children in their ...
Tillmanns, Maria daVenza
core