Results 171 to 180 of about 145,125 (343)

Evaluation of the CRISPR/Cas9 system as genome editing platform for the Mucopolysaccharidosis IV A using a strategy for induction of higher homologous recombination frequency

Universitas Scientiarum
Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the gene encoding for the hydrolase N-acetylgalactose-6-sulfate sulfatase (GALNS). GALNS deficiency leads to a progressive buildup of partially degraded chondroitin-
Diego Alejandro Suarez, Andrés Felipe Leal, Carlos Javier Alméciga Díaz   +2 more
doaj   +1 more source

METAB-LATAM: SHARING OF SCIENTIFIC KNOWLEDGE IN INBORN ERRORS OF METABOLISM

, 2023
Eliana M. Martínez Bazán, Andrei Meurer de Andrade, Patricia Ribeiro Rigo, Dévora Randon, Thiago Oliveira Silva, Ida Vanessa Döederlein Schwartz   +5 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Inborn anemias in mice. Comprehensive progress report, May 1, 1970--April 30, 1973

, 1973
Elizabeth S. Russell, S E Bernstein
openalex   +2 more sources

Function of Fast Reflexion in Bipolar choice [PDF]

, 2002
Our view of "reflexion" has been essentially broadened during the last twenty years. Traditionally we have considered it to consist of the conscious constructing of images of the self and others by human beings.
Adams-Webber, Jack, Lefebvre, Vladimir A.   +1 more
core  

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity.

Journal of Allergy and Clinical Immunology: In Practice, 2019
M. Seidel, G. Kindle, B. Gathmann, I. Quinti, M. Buckland, J. V. van Montfrans, Raphael Scheible, Stephan Rusch, Lukas M Gasteiger, B. Grimbacher, N. Mahlaoui, S. Ehl   +11 more
semanticscholar   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

The role of exome sequencing in newborn screening for inborn errors of metabolism

Nature Medicine, 2020
Aashish N. Adhikari, R. Gallagher, Yaqiong Wang, R. Currier, George S. Amatuni, Laia Bassaganyas, Flavia Chen, Kunal Kundu, M. Kvale, S. Mooney, R. Nussbaum, S. Randi, J. Sanford, Joseph T C Shieh, Rajgopal Srinivasan, Uma Sunderam, Hao Tang, Dedeepya Vaka, Yang Zou, B. Koenig, P. Kwok, N. Risch, J. Puck, S. Brenner   +23 more
semanticscholar   +1 more source

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Qingguo Du, Wen‐Xue Li   +7 more
wiley   +1 more source