Results 131 to 140 of about 39,677 (355)
iMeta, EarlyView.By integrating multi‐level and multi‐omics analyses, we identify 3,4‐dihydroxyphenylacetic acid (DHPAA), a gut microbiota‐derived degradation product of dietary flavonoids, as a key bioactive end‐product responsible for the beneficial effects against polycystic ovary syndrome (PCOS).
Pan Li +22 more
wiley +1 more source
Alpha-ketoadipic aciduria, a new inborn error of lysine metabolism; biochemical studies [PDF]
, 1975 Hildegard Przyrembel +6 more
openalex +1 more source
Newborn screening for inborn errors of metabolism and endocrinopathies: an update [PDF]
, 2018 Newborn screening for inborn errors of metabolism and endocrinopathies has expanded during the last two decades, mainly owing to the introduction of new technologies such as tandem mass spectrometry and DNA analysis.
Fingerhut, Ralph, Olgemöller, Bernhard
core
Intralitter Variability Influences the Developmental Impact of Valproic Acid Exposure in CD‐1 Mice
Journal of Applied Toxicology, EarlyView.ABSTRACT Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug that causes teratogenic effects, including neural tube defects (NTDs), when taken during pregnancy. Although animal models are widely used to study VPA teratogenicity, most rely on litter means, which overlook variability within the litter.
Lauren T. L. Brown +3 more
wiley +1 more source
Saliva as a TDM matrix and its application in the model‐informed precision dosing
The Journal of Clinical Pharmacology, EarlyView.Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu +9 more
wiley +1 more source
A community-driven global reconstruction of human metabolism [PDF]
, 2013 Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human ...
Hucka, Michael, Thiele, Ines
core +1 more source
Not So Rare: Errors of Metabolism during the Neonatal Period
, 2003 During the neonatal period, the diagnosis of an error of metabolism (EM) was once thought to portend a poor prognosis or lethality. Over the past two decades, the prognosis of many EMs has changed.
Banta-Wright, Sandra, Steiner, Robert D.
core +1 more source
Journal of Hospital Medicine, EarlyView.Abstract Background Guidelines on Brief Resolved Unexplained Event (BRUE) only provide recommendations for infants categorized at lower risk. However, most infants fall into the higher‐risk category, leaving management decisions to individual clinicians and contributing to variation in care.
Nassr Nama +18 more
wiley +1 more source
Combined immunodeficiency and inborn errors of purine metabolism [PDF]
, 1978 H.J. Meuwissen, Bernard Pollara
openalex +1 more source