Results 271 to 280 of about 2,729,552 (357)

A multiomic network approach uncovers disease modifying mechanisms of inborn errors of metabolism

Bender A, Ranea-Robles P, Williams EG, Mirzaian M, Heimel JA, Levelt CN, Wanders RJ, Aerts JM, Zhu J, Auwerx J, Houten SM, Argmann CA.   +11 more
europepmc   +1 more source

Genomic insights on conservation priorities for North Sea houting and European lake whitefish (Coregonus spp.)

Molecular Ecology, EarlyView.
Abstract Population genomics analysis holds great potential for informing conservation of endangered populations. We focused on a controversial case of European whitefish (Coregonus spp.) populations. The endangered North Sea houting is the only coregonid fish that tolerates oceanic salinities and was previously considered a species (C.
Aja Noersgaard Buur Tengstedt, Shenglin Liu, Magnus W. Jacobsen, Camilla Gundlund, Peter Rask Møller, Søren Berg, Dorte Bekkevold, Michael M. Hansen   +7 more
wiley   +1 more source

Selection on genome‐wide gene expression plasticity of rice in wet and dry field environments

Molecular Ecology, EarlyView.
Abstract Gene expression can be highly plastic in response to environmental variation. However, we know little about how expression plasticity is shaped by natural selection and evolves in wild and domesticated species. We used genotypic selection analysis to characterize selection on drought‐induced plasticity of over 7,500 leaf transcripts of 118 ...
Elena Hamann, Simon C. Groen, Taryn S. Dunivant, Irina Ćalić, Colleen Cochran, Rachel Konshok, Michael D. Purugganan, Steven J. Franks   +7 more
wiley   +1 more source

Identification of the molecular defect in patients with peroxisomal mosaicism using a novel method involving culturing of cells at 40°C: Implications for other inborn errors of metabolism

, 2004
Jeannette Gootjes, Frank Schmohl, Petra A.W. Mooijer, Conny Dekker, Hanna Mandel, Meral Topçu, Martina Huemer, Marco Schütz, Thorsten Marquardt, Jan Smeitink, Hans R. Waterham, Ronald J. A. Wanders   +11 more
openalex   +1 more source

Local Selection Shaped the Diversity of European Maize Landraces

Molecular Ecology, EarlyView.
ABSTRACT The introduction of populations to novel environments can lead to a loss of genetic diversity and the accumulation of deleterious mutations due to selection and demographic changes. We investigate how the recent introduction of maize to Europe shaped the genetic diversity and differentiation of European traditional maize populations and ...
Margarita Takou, Kerstin Schulz, Markus G. Stetter   +2 more
wiley   +1 more source

Rapid Neural DNA Methylation Responses to Predation Stress in Trinidadian Guppies

Molecular Ecology, EarlyView.
ABSTRACT DNA methylation (DNAm) is a well‐studied epigenetic mechanism implicated in environmentally induced phenotypes and phenotypic plasticity. However, few studies investigate the timescale of DNAm shifts. Thus, it is uncertain whether DNAm can change on timescales relevant for rapid phenotypic shifts, such as during the expression of short‐term ...
Janay A. Fox, Simon M. Reader, Rowan D. H. Barrett   +2 more
wiley   +1 more source

Liver Transplantation for Inborn Errors of Metabolism

, 2005
Jochen Meyburg, Georg F. Hoffmann
openalex   +1 more source

Harnessing Next-Generation Sequencing as a Timely and Accurate Second-Tier Screening Test for Newborn Screening of Inborn Errors of Metabolism. [PDF]

Int J Neonatal Screen
Chan TCH, Mak CM, Yeung MCW, Law EC, Cheung J, Wong TK, Cheng VW, Lee JKH, Wong JCL, Fung CW, Belaramani KM, Kwok AMK, Tsang KY.   +12 more
europepmc   +1 more source

The Long‐Term Effects of In Utero Exposure to Rubella

Oxford Bulletin of Economics and Statistics, EarlyView.
ABSTRACT A rubella infection in early pregnancy poses a significant risk of damage to the foetus. In this paper, we examine the later‐life impact of a rubella outbreak that occurred in Ireland in 1956. Matching the outcomes of individuals born in 1954–1957 in the 2016 Irish Census of Population to the county‐level rubella incidence rate that was ...
Irene Mosca, Anne Nolan
wiley   +1 more source

Markers Associated with Inborn Errors of Metabolism of Branched-Chain Amino Acids and Their Relevance to Upper Levels of Intake in Healthy People: An Implication from Clinical and Molecular Investigations on Maple Syrup Urine Disease

, 2005
Hiroshi Mitsubuchi, Misao Ōwada, Fumio Endo   +2 more
openalex   +1 more source