Results 181 to 190 of about 411,751 (305)

The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Cancer Science, EarlyView.
Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng   +10 more
wiley   +1 more source

High-density single nucleotide polymorphism markers analysis reveals the genetic diversity and population structure in tropical highland maize (Zea mays L.) inbred lines. [PDF]

PLoS One
Gebre WT, Ababulgu DA, Negassa TM, Senbeta TF.   +3 more
europepmc   +1 more source

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

Clinical Genetics, EarlyView.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady, Hadar Hulin Ma'ayan, Michal Cohen, Karin Weiss   +3 more
wiley   +1 more source

Inbreeding depression in diploid potato: genetic basis, deleterious load, and breeding mitigation. [PDF]

Front Plant Sci
Wang Y, Lin T, Wang W, Wang Y, Fan L, Huang W, Jiao X, Wang Z, Wu H, Zong X, Zheng A, Yang F, Zhang B, Yu J, Chen J, Yin Y.   +15 more
europepmc   +1 more source

Algorithms in Allergy: Diagnosis of Hypereosinophilic Syndromes, 2026 Update

Allergy, EarlyView.
Guillaume Lefèvre, Florence Roufosse, Giacomo Emmi, Andreas Reiter, Emmanuel Ledoult, Jean‐Emmanuel Kahn   +5 more
wiley   +1 more source

The Politics of Othering in the 'Happy Soul': Historicising Abjection in the Promise of Joy for Childhood and Play

Children &Society, EarlyView.
ABSTRACT This article interrogates the politics of othering embedded in the taken‐for‐granted association of childhood, play, joy, and happiness. It explores how these notions are historically inscribed as forms of otherness tied to the affective normativity of joy.
Chushan Wu
wiley   +1 more source

Genome-Wide Association Mapping of Ear Traits in Early-Maturing Maize Under Contrasting Planting Densities. [PDF]

Int J Mol Sci
Jiang L, Chen S, Gao Y, Zhang T, Wang H, Wang R, Zheng A, Jiang M, Wang Y, Zhang H.   +9 more
europepmc   +1 more source

Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ...
Shrina Patel, Brad Graham, Kaci Reaves, Mya Phelps   +3 more
wiley   +1 more source

Implications of dominance deviations for reproductive and morphological traits in the genetic management of the Pura Raza Española horse. [PDF]

Genet Sel Evol
Perdomo-González DI, Valera M, Molina A, Azor P, Sánchez JP.   +4 more
europepmc   +1 more source

Bioethics and the World Order: A Curious Coincidence Between Chinese and African Approaches

Developing World Bioethics, EarlyView.
ABSTRACT The post‐1945 world order is standardly pictured as a Westphalian system, in which each state is equal under the law with sovereign authority over its territories. This paper argues that the Westphalian system is changing and examines the implications for bioethics. We show that cross‐border health, economic, ecologic, and sociopolitical risks
Nancy S. Jecker, Jing‐Bao Nie, Anita Ho   +2 more
wiley   +1 more source