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Two new inbred rat strains derived from SHR: WKHA, hyperactive, and WKHT, hypertensive, rats
American Journal of Physiology-Heart and Circulatory Physiology, 1991Two new strains of inbred rats have been developed. One, WKHA, exhibits hyperactivity, and the other, WKHT, exhibits hypertension. Both of these traits are expressed in the SHR. By crossing spontaneously hypertensive rats (SHRs) with Wistar-Kyoto (WKY) controls, followed by recombinant selected inbreeding, we succeeded in genetically separating the ...
E D, Hendley, W G, Ohlsson
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[Effect of captopril on urinary 6-keto-PGF1 alpha, thromboxane B2 in inbred SHR rats].
Zhonghua xin xue guan bing za zhi, 1992Urinary 6-keto-PGF1 alpha, TXB2, PRA, ATII, blood pressure, urine volume, urinary sodium and potassium were measured by RIA in SHR after administration of captopril and indomethacin. The results suggested that captopril would significantly decrease ATII, and showed marked effects of hypotension, diuresis and caused variation of PG system.
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