Results 101 to 110 of about 2,317,355 (365)

Innate immune basis for rift valley fever susceptibility in mouse models [PDF]

, 2017
Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the
Bruhns, Pierre, Flamand, Marie, Godon, Ophélie, Jouvion, Grégory, Lathan, Rashida, Malissen, Marie, Panthier, Jean-Jacques, Simon-Chazottes, Dominique   +7 more
core   +2 more sources

Effects of Aging on Glucose and Lipid Metabolism in Mice

Aging Cell, Volume 24, Issue 4, April 2025.
Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit evidence of upregulated fatty acid and sphingolipid metabolism reactions that regenerate NAD+ from NADH.
Evan C. Lien, Ngoc Vu, Anna M. Westermark, Laura V. Danai, Allison N. Lau, Yetiş Gültekin, Matthew A. Kukurugya, Bryson D. Bennett, Matthew G. Vander Heiden   +8 more
wiley   +1 more source

Quality of Reporting and Adherence to ARRIVE Guidelines in Animal Studies for Chagas Disease Preclinical Drug Research: A Systematic Review [PDF]

, 2015
Publication of accurate and detailed descriptions of methods in research articles involving animals is essential for health scientists to accurately interpret published data, evaluate results and replicate findings. Inadequate reporting of key aspects of
García Bournissen, Facundo, Gulin, Julián Ernesto Nicolás, Rocco, Daniela Marisa   +2 more
core   +4 more sources

Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes.

Genome Research, 2003
Identifying complex-trait candidate genes after initial low-resolution mapping has proven to be a difficult and labor-intensive undertaking, usually requiring years to develop and analyze congenic strains.
Yeong-Gwon Park, R. Clifford, K. Buetow, K. Hunter   +3 more
semanticscholar   +1 more source

Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice

Aging Cell, Volume 24, Issue 5, May 2025.
An endochondral differentiation process in the CEPs drives pathologic disc calcification in aging LG/J mice, and NP cell hypertrophic transdifferentiation secondarily contributes. Supplementing drinking water with 80 mM K3Citrate during aging markedly reduced disc calcification, attenuated NP cell transdifferentiation, and mildly improved NP and AF ...
Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud   +9 more
wiley   +1 more source

The role of host PrP in Transmissible Spongiform Encephalopathies [PDF]

, 2007
PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent.
.Nazor, Asano, Asante, Asante, Barron, Barron, Barron, Baylis, Billeter, Brandel, Bruce, Bueler, Cancellotti, Carlson, Cervenakova, DeArmond, Enrico Cancellotti, Fioriti, Frances Wiseman, Hill, Hsiao, Hsiao, Ironside, Jean C. Manson, Korth, Kretzschmar, Lehmann, Lewis, Lloyd, Ma, Ma, Manolakou, Manson, Manson, Matthew T. Bishop, Moore, Neuendorf, Nurmi, Patricia Hart, Peden, Peretz, Priola, Priola, Prusiner, Prusiner, Rogers, Rona M. Barron, Rudd, Safar, Scott, Scott, Somerville, Stephenson, Stimson, Taguchi, van Rheede, Wadsworth, Will, Winklhofer   +58 more
core   +3 more sources

The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders

Aging Cell, EarlyView.
Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim, Hye Sun Go, Eun Jae Jeon, Thi Quynh Trang Nguyen, Da Yeon Kim, Hansung Park, Hyo‐Ji Eom, Sung Young Kim, Sang Chul Park, Kyung A Cho   +9 more
wiley   +1 more source

Deciphering the chemical language of inbred and wild mouse conspecific scents

eLife
In most mammals, conspecific chemosensory communication relies on semiochemical release within complex bodily secretions and subsequent stimulus detection by the vomeronasal organ (VNO).
Maximilian Nagel, Marco Niestroj, Rohini Bansal, David Fleck, Angelika Lampert, Romana Stopkova, Pavel Stopka, Yoram Ben-Shaul, Marc Spehr   +8 more
doaj   +1 more source

Genetic improvement of the herbivorous blunt snout bream (Megalobrama amblycephala) [PDF]

, 2003
Selection experiments with the herbivorous blunt snout bream or Wuchang bream (Megalobrama amblycephala) were started in 1985. Mass selection for size and length/depth ratio resulted in a significant increase in growth and better shape, while inbreeding ...
Cai, W.Q., Li, S.F.
core  

The Mitochondria‐Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age

Aging Cell, EarlyView.
The effects of the mitochondria‐targeted peptide therapeutic elamipretide on age‐related muscle function were compared with its effects on molecular biomarkers of aging. It was found that elamipretide treatment partially reverses age‐related cardiac dysfunction and skeletal muscle weakness in mice without significantly affecting muscle epigenetic or ...
Wayne Mitchell, Gavin Pharaoh, Alexander Tyshkovskiy, Matthew Campbell, David J. Marcinek, Vadim N. Gladyshev   +5 more
wiley   +1 more source