Results 111 to 120 of about 2,317,355 (365)

SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

Cell Genomics, 2022
Summary: Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains.
Milad Mortazavi, Yangsu Ren, Shubham Saini, Danny Antaki, Celine L. St. Pierre, April Williams, Abhishek Sohni, Miles F. Wilkinson, Melissa Gymrek, Jonathan Sebat, Abraham A. Palmer   +10 more
doaj  

Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

Frontiers in Genetics, 2019
GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function.
Megan K. Mulligan, Timothy Abreo, Sarah M. Neuner, Sarah M. Neuner, Cory Parks, Christine E. Watkins, M. Trevor Houseal, Thomas M. Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang, Jesse Ingels, Junmin Peng, Lu Lu, Catherine C. Kaczorowski, Camron D. Bryant, Gregg E. Homanics, Robert W. Williams   +17 more
doaj   +1 more source

An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth.

British Journal of Cancer, 1980
Intra-oral squamous-cell carcinomas occurred in over 50% of the HMT inbred strain of rats. In the outbred stock from which it was derived the incidence was 5% or less, both when inbreeding was begun and after the inbred strain was fully established ...
P. Buckley, E. Hulse, B. M. Keep
semanticscholar   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, EarlyView.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Resistance Evaluation of Radish (Raphanus sativus L.) Inbred Lines against Turnip mosaic virus

Research in Plant Disease, 2017
Leaves of twenties radish (Raphanus sativus L.) inbred lines were mechanically inoculated with Turnip mosaic virus (TuMV) strain HY to evaluate TuMV resistance of the radish inbred lines.
Ju-Yeon Yoon, Gug-Seoun Choi, Su Kim, Seung-Kook Choi   +3 more
doaj   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Absence of pregnancy-block in mice when stud and test males belong to an inbred strain.

Journal of Reproduction and Fertility, 1968
The recently-mated female mouse can be removed from her stud partner within a few hours of coitus and returned to him 24 hr later without disturbance to the pregnancy.
H. M. Bruce
semanticscholar   +1 more source

Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

Aging Cell, EarlyView.
Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang, Jian Yang, Yue Luo, Zhiqiang Zhao, Yawen Yuan, Juan Li, Yang Liu, Yong Yi, Xiaoke Xu, Yuankunyu Lan, Juan Zou, Qintong Li, Liang Wang, Yang Pan, Yuanhan Yang, Muzhao Xiong, Min Wu, Jinsong Li, Weiyuxin Li, Yujun Zhang, Yang Cao, Yi Zhu, Zhi‐Xiong Jim Xiao   +22 more
wiley   +1 more source

Inter-strain differences of serotonergic inhibitory pain control in inbred mice

Molecular Pain, 2010
Background Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Myrczek Thekla, Häussler Annett, Albuquerque Boris, Wijnvoord Nina, Popp Laura, Tegeder Irmgard   +5 more
doaj   +1 more source

CA1 Spike Timing is Impaired in the 129S Inbred Strain During Cognitive Tasks. [PDF]

Neuroscience, 2022
Adeyelu T, Shrestha A, Adeniyi PA, Lee CC, Ogundele OM.   +4 more
europepmc   +1 more source