Results 171 to 180 of about 1,429,370 (225)
Entering the Age of Specificity in T Cell Immunity
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley +1 more source
The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity
In maize, ZmRACK1 acts as a scaffold protein that bridges the cyclin‐dependent kinase ZmCDPK7 and the ascorbate peroxidase ZmAPX1, promoting ZmAPX1 activity to mitigate MCMV infection. Upon viral infection, P31 obstructs formation of the ZmRACK1‐ZmCDPK7‐ZmAPX1 complex, inhibiting ZmCDPK7‐mediated ZmAPX1 activity and promoting reactive oxygen species ...
Yuyang Zhang +13 more
wiley +1 more source
ABSTRACT Objective This study aims to investigate the effect of sex, anesthesia administration method, lymphatic physiological asymmetry, and strain on popliteal lymphatic collecting vessel contractile function and transport in effort to create a research comparison standard for experimentations using rat popliteal lymphatics.
Sophia Mavris +5 more
wiley +1 more source
Genetic modulation of oxycodone self-administration trajectories: from initiation to escalating burst patterns. [PDF]
Hodges CI +7 more
europepmc +1 more source
Natural Variation in GmSL20 Improves Seed Size and Quality in Soybean
ABSTRACT Seed size plays an important role in determining crop yield, yet the genetic mechanisms underlying the regulation of this agronomic trait remain incompletely understood in soybean. Here, we perform a genome‐wide association study mapping with seed length variations and identify a major quantitative trait locus (QTL) on chromosome 20, named ...
Yuechuan Luo +12 more
wiley +1 more source
ABSTRACT Jasmonate (JA) regulates defence responses in plants. However, JA‐induced defence often results in growth inhibition. This process is largely mediated by MYC2, the master regulator of JA signalling. Nevertheless, the underlying molecular mechanisms have not yet been fully uncovered.
Luyan Zhao +3 more
wiley +1 more source
Benchmarking genomic variant calling tools in inbred mouse strains: recommendations and considerations. [PDF]
Garretson A +3 more
europepmc +1 more source
ABSTRACT Trichuris trichiura is one of the soil transmitted geohelminths which together currently affect approximately 25% of the global population resulting in considerable morbidity particularly in children and young adults. Recent estimates put infection by T. trichiura at approximately 513 million.
Allison J. Bancroft +8 more
wiley +1 more source
Outbred mice as an appropriate model for evaluating the immunogenicity of vaccines against porcine circovirus 2. [PDF]
Martins VBF +9 more
europepmc +1 more source
SUMMARY Grain weight is a key determinant of wheat yield, yet the developmental mechanisms that define this trait remain poorly understood. Here, we identify TaPGW1‐A1, a wheat‐specific proline‐rich gene that regulates grain weight. TaPGW1‐A1 is a recently evolved gene found only in wheat.
Li Guo +9 more
wiley +1 more source

