Results 31 to 40 of about 120,683 (236)

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source

Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. [PDF]

PLoS ONE, 2010
Progressive sensorineural hearing loss is the most common form of acquired hearing impairment in the human population. It is also highly prevalent in inbred strains of mice, providing an experimental avenue to systematically map genetic risk factors and ...
Konrad Noben-Trauth, Joseph R Latoche, Harold R Neely, Beth Bennett   +3 more
doaj   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.

PLoS Genetics
The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations for over a century. However, laboratory mice capture only a subset of the genetic variation found in wild mouse populations, ultimately ...
Beth L Dumont, Daniel M Gatti, Mallory A Ballinger, Dana Lin, Megan Phifer-Rixey, Michael J Sheehan, Taichi A Suzuki, Lydia K Wooldridge, Hilda Opoku Frempong, Raman Akinyanju Lawal, Gary A Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K White, Michael W Nachman   +14 more
doaj   +1 more source

Gene - environment interaction in programming hippocampal plasticity: focus on adult neurogenesis

Frontiers in Molecular Neuroscience, 2015
Interactions between genes and environment are a critical feature of development and both contribute to shape individuality. They are at the chore of vulnerability / resiliency for mental illnesses.
Muriel eKoehl, Muriel eKoehl
doaj   +1 more source

The collaborative cross strains and their founders vary widely in cocaine-induced behavioral sensitization

Frontiers in Behavioral Neuroscience, 2022
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United States in the last 10 years. Despite the prevalence of cocaine use disorder (CUD) and the personal and societal problems it presents, there are currently no ...
Sarah A. Schoenrock, Sarah A. Schoenrock, Leona Gagnon, Leona Gagnon, Ashley Olson, Ashley Olson, Michael Leonardo, Michael Leonardo, Vivek M. Philip, Vivek M. Philip, Hao He, Hao He, Laura G. Reinholdt, Laura G. Reinholdt, Stacey J. Sukoff Rizzo, Stacey J. Sukoff Rizzo, Stacey J. Sukoff Rizzo, James D. Jentsch, James D. Jentsch, Elissa J. Chesler, Elissa J. Chesler, Lisa M. Tarantino, Lisa M. Tarantino, Lisa M. Tarantino   +23 more
doaj   +1 more source

Born this way: Does variation in perinatal limb bone morphology predict adult locomotor repertoire in primates?

The Anatomical Record, EarlyView.
Abstract Primates show a high degree of locomotor diversity that engenders similar variance in limb bone cross‐sectional geometry and bending strength: leaping primates have stronger hindlimb bones whereas suspensory species have stronger forelimb bones.
Angela M. Mossor, Jeremy Busken, Lorna Benden, Ethan Mardovin, Andrew Bostick, Grégoire Boulinguez‐Ambroise, Timothy D. Smith, Jesse W. Young   +7 more
wiley   +1 more source

Traffic Noise Exposure Increases Gastric Acid Secretion in Rat [PDF]

Acta Medica Iranica, 2010
Noise is considered as one of the most severe sources of environmental and work place constraints. Noise effects on immune function, hormonal levels, cardiovascular and respiratory systems are well known.
Azam Moslehi, Fatemeh Nabavizadeh-Rafsanjani, Mansoor Keshavarz, Nematollah Rouhbakhsh, Masoud Sotudeh, Ehsan Salimi   +5 more
doaj   +2 more sources

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science
A more complete map of the pattern of genetic variation among inbred mouse strains is essential for characterizing the genetic architecture of the many available mouse genetic models of important biomedical traits.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
doaj   +1 more source

Genetic Relationships Between Ethanol-Induced Conditioned Place Aversion and Other Ethanol Phenotypes in 15 Inbred Mouse Strains

Brain Sciences, 2019
The genetic relationships between different behaviors used to index the aversive effects of ethanol are unknown. To address this issue, ethanol-induced conditioned place aversion (CPA) was tested in a genetically diverse panel of 15 inbred mouse strains.
Christopher L. Cunningham
doaj   +1 more source