Results 81 to 90 of about 119,767 (218)

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV‐induced skin carcinogenesis studies [PDF]

, 2011
Carlos J. Pérez, Jan Parker‐Thornburg, Carol Mikulec, Donna F. Kusewitt, Susan M. Fischer, John DiGiovanni, Claudio J. Conti, Fernando Benavides   +7 more
openalex   +1 more source

The power of a stewardship mind: Reorienting organizations around the duty to care to better address grand challenges

International Journal of Management Reviews, EarlyView.
Abstract The present article presents an integrative review related to stewardship in all the business and management disciplines, from its initial development in 1980 to the present. Specifically, we applied a latent Dirichlet allocation‐based topic modelling analysis to almost 1200 articles, seeking to creatively synthesize the concept of stewardship
Debora Casoli, Marco Visentin, Annamaria Tuan, Giuseppe Cappiello   +3 more
wiley   +1 more source

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site. [PDF]

Heredity (Edinb), 2021
Chebib J, Jackson BC, López-Cortegano E, Tautz D, Keightley PD.   +4 more
europepmc   +1 more source

Effect of Hybridization on the Primary Polydipsic Trait of an Inbred Strain of Mice [PDF]

, 1961
Emanuel Silverstein
openalex   +1 more source

Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models [PDF]

, 2023
Beth L. Dumont, Daniel M. Gatti, Mallory A. Ballinger, Dana Lin, Megan Phifer‐Rixey, Michael J. Sheehan, Taichi A. Suzuki, Lydia K. Wooldridge, Hilda Opoku Frempong, Gary A. Churchill, Cathleen Lutz, Nadia Rosenthal, Jacqueline K. White, Michael W. Nachman   +13 more
openalex   +1 more source

The maize mitogen‐activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance

New Phytologist, EarlyView.
Summary Southern leaf blight (SLB), caused by the necrotrophic fungus Cochliobolus heterostrophus, is a major foliar disease of maize (Zea mays) world‐wide. A genome‐wide association study was performed to dissect the genetic basis of SLB resistance in maize. Functional validation was performed using mutant and transgenic analyses.
Tao Zhong, Bode Olukolu, Yang Bian, Shang Xue, Randall J. Wisser, Peter S. Ojiambo, James B. Holland, Qin Yang, Peter Balint‐Kurti   +8 more
wiley   +1 more source

ClAPRT3‐Mediated Adenine Salvage Pathway Enhances Purine Metabolites to Sustain Seed Vigour During Selfing in Cunninghamia lanceolata

Plant Biotechnology Journal, EarlyView.
ABSTRACT Selfing often causes inbreeding depression, especially during seed and seedling stages. However, some selfed progeny show low inbreeding depression with enhanced vigour, differing from inbred counterparts. This study investigates the molecular mechanisms maintaining seed vigour during selfing in Cunninghamia lanceolata.
Houyin Deng, Ye Zhao, Jie Liu, Kunjin Han, Juan Han, Meng Ke, Rong Huang, Ruping Wei, Yousry A. El‐Kassaby, Runhui Wang, Shu Yan, Yuhan Sun, Yun Li, Huiquan Zheng   +13 more
wiley   +1 more source

Trans‐QTL Alliance of HKT1 and PHL7 Modulate Salinity Stress Tolerance and Enhance Crop Yield Endurance

Plant Biotechnology Journal, EarlyView.
ABSTRACT Salinity stress can cause significant yield losses in crops because of its major impact on reproductive success. The complexity of salinity stress responses, particularly their tissue‐ and cell‐specific regulation, continues to challenge the translation of molecular insights into tangible crop yield improvements.
Jitendra K. Mohanty, Antima Yadav, Laxmi Narnoliya, Virevol Thakro, Deepanshi Rathore, Shailesh Tripathi, Senjuti Sinharoy, Pinky Agarwal, Swarup K. Parida   +8 more
wiley   +1 more source

Establishment of a zebrafish inbred strain, M-AB, capable of regular breeding and genetic manipulation

Scientific Reports
Inbred strains of organisms are genetically highly uniform and thus useful for life science research. We have previously reported the ongoing generation of the zebrafish IM strain from the India (IND) strain through full sib-pair mating for 16 ...
Kenichiro Sadamitsu, Fabien Velilla, Minori Shinya, Makoto Kashima, Yukiko Imai, Toshihiro Kawasaki, Kenta Watai, Miho Hosaka, Hiromi Hirata, Noriyoshi Sakai   +9 more
doaj   +1 more source