Results 41 to 50 of about 49,672 (246)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Accounting for animal health in efficiency analysis: An application to Swedish dairy farms

American Journal of Agricultural Economics, EarlyView.
Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang, Enoch Owusu‐Sekyere, Karin Alvåsen, Helena Hansson   +3 more
wiley   +1 more source

Illness as a valid reason for restoring the term of inheritance acceptance

Правоприменение
The subject. Compliance with the term for the implementation of the inheritance rights for persons wishing to become successors of a deceased citizen is an important condition for acquiring rights to hereditary property.
E. A. Khodyreva, P. M. Khodyrev
doaj   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Nonspecific chronic low back pain and incapacity level: influence of walking performance

Revista Dor, 2017
BACKGROUND AND OBJECTIVES: Chronic low back pain syndrome promotes several functional losses which impact quality of life of patients, and walking is one of the most impaired functions.
Alberito Rodrigo de Carvalho, Welds Rodrigo Ribeiro Bertor, Ricardo Massao Abico, Lana Brandl, Thiago Fernando Mattjie, Alexandro Andrade, Leonardo Alexandre Peyré-Tartaruga   +6 more
doaj   +1 more source

Socio-economic consequences of mental distress: quantifying the impact of self-reported mental distress on the days of incapacity to work and medical costs in a two-year period: a longitudinal study in Germany

BMC Public Health, 2021
Background Mental disorders are related to high individual suffering and significant socio-economic burdens. However, it remains unclear to what extent self-reported mental distress is related to individuals’ days of incapacity to work and their medical ...
Gerhard Müller, Manuela Bombana, Monika Heinzel-Gutenbrenner, Nikolaus Kleindienst, Martin Bohus, Lisa Lyssenko, Ruben Vonderlin   +6 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Medical Incapacity Management in the South African private industrial sector: The role of the occupational therapist

South African Journal of Occupational Therapy, 2019
Background: Occupational therapists working in the field of occupational health in South African private industrial sectors  may find themselves involved in management of medical incapacity due to their expertise in vocational rehabilitation.
Ravashni Govender, Pragashnie Govender, December Mandlenkosi Mpanza   +2 more
doaj   +1 more source

Otherwise engaged? Learning from non‐participation in research with care‐experienced students

British Educational Research Journal, EarlyView.
Abstract This paper explores what can be learned when educational research “fails.” Drawing on a Welland Trust–funded project in the North East of England that aimed to support care‐experienced students transitioning from further to higher education, we reflect on why, despite sustained effort, there was a lack of engagement.
Lynette Harland Shotton, Tom Disney, Andrea Carrick, Laura Thurman   +3 more
wiley   +1 more source

MINORS AND THEIR INCAPACITY TO CONTRACT: A REVISIT

UUM Journal of Legal Studies, 2023
Given the exposure to today's easy-to-know information, children should seemingly become mature faster than their predecessors, and therefore better informed even at a tender age.
Rosmawani Che Hashim, Farah Nini Dusuki
doaj   +1 more source