Results 171 to 180 of about 1,793,238 (381)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Congestion-Aware Incentive Scheme Based on Double Auction for DTN
Dianxin kexue, 2015 To stimulate the DTN selfish nodes to cooperatively forward messages when the buffer was limited, a congestion-aware incentive scheme based on double auction for DTN was proposed.
Qingfeng Jiang +3 more
doaj
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Infrastructure Investment in Network Industries: The Role of Incentive Regulation and Regulatory Independence [PDF]
This paper finds that coherent regulatory policies can boost investment in network industries of OECD economies. Rate-of-return regulation is generally thought to result in overinvestment, while incentive regulation is believed to entail underinvestment.
Balazs Egert
core
Managerial Incentive Problems: A Dynamic Perspective
, 1999 Bengt R. Holmstrom
semanticscholar +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Incentive-compatible Fiscal Constitutions [PDF]
It is a fact that in most of the countries (both currently and historically) the wealthier a person is, the higher the amount that he or she has to pay in taxes.
Andrés Carvajal
core
Erratum to: The effect of varied reinforcement training on behavior following incentive reduction [PDF]
, 1968 Stephen F. Davis, Alvin J. North
openalex +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source