Results 251 to 260 of about 288,149 (316)

A Review of Medical Data Sharing Initiatives With a Focus on the Use of Blockchain Technologies: Qualitative Comparative Analysis. [PDF]

J Med Internet Res
Cunningham J, Davies N, Devaney S, Harding M, Holm S, Neumann V, Smith C, Ainsworth J.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

HyAR-PPO: Hybrid Action Representation Learning for Incentive-Driven Task Offloading in Vehicular Edge Computing. [PDF]

Sensors (Basel)
Wang W, Li M, Wu H.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effects of incentive spirometer training on dyspnea and functional status in patients with long COVID. [PDF]

PLoS One
Chen YH, Lin CH, Liu JH, Lin HA, Hsieh YS.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Promoting deceased organ donation: should familist incentives be adopted in Islamic regions? [PDF]

Theor Med Bioeth
Siraj S, Fan R.
europepmc   +1 more source

Progressing from Simple to Multidimensional Models Towards a Biopsychosocial Framework of Addiction. [PDF]

Curr Addict Rep
Regier PS.
europepmc   +1 more source

Factors influencing performance motivation of Accredited Social Health Activists, the community health volunteers of India - A mixed method study. [PDF]

J Family Med Prim Care
Sharma R, Gulati S, Panigrahi G, Kumar A, Singh GB, Kotwal A.   +5 more
europepmc   +1 more source

Bounding the costs of electric vehicle managed charging-supply curves for scenarios from 2025 to 2050. [PDF]

Sci Data
Matsuda-Dunn R, Hale E, Estreich E, Lavin L, Konar-Steenberg G.   +4 more
europepmc   +1 more source