Results 61 to 70 of about 5,619,681 (327)
On the development and practice of translational medicine
生物医学转化, 2021 Translational medicine is an innovative research model that connects basic research and clinicalapplication. The development of translational medicine and the promotion of the transformation of results can provide advanced concepts and methods for the ...
Ayixiemuguli·Alimas, Wen Hao
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Transient interference of transmission and incidence [PDF]
, 2000 Due to a transient quantum interference during a wavepacket collision with a potential barrier, a particular momentum, that depends on the potential parameters but is close to the initial average momentum, becomes suppressed.
A. H. Zewail +9 more
core +2 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Journal of Pure and Applied Algebra, 2011 Given a family $\F$ of posets closed under disjoint unions and the operation of taking convex subposets, we construct a category $\C_{\F}$ called the \emph{incidence category of $\F$}. This category is "nearly abelian" in the sense that all morphisms have kernels/cokernels, and possesses a symmetric monoidal structure akin to direct sum.
openaire +2 more sources
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Incidence Bounds for Block Designs
, 2016 We prove three theorems giving extremal bounds on the incidence structures determined by subsets of the points and blocks of a balanced incomplete block design (BIBD).
Lund, Ben, Saraf, Shubhangi
core +1 more source
Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern [PDF]
, 1999 Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap.
Klauss, V. +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Historical Patterns of Arboviral Seroprevalence across Africa and Asia [PDF]
, 2017 The emergence and resurgence of arboviruses in recent history is challenging our scientific understanding of mosquito-borne diseases and their transmission.
Chrisafis, George C
core +1 more source