Results 71 to 80 of about 5,619,681 (327)

Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women: Improper Recommendations [PDF]

, 2008
Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs.
Bognár, M., Constantin, Tamás, Garami, Miklós, Hauser, Péter, Jakab, Zsuzsanna, Müller, Judit, Ponyi, Andrea, Schuler, Dezső   +7 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury

Frontiers in Pharmacology
ObjectiveSepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication in septic patients. This study combines network pharmacology with in vitro and in vivo experiments to preliminarily investigate the protective effect of ...
Xuan Gou, Xuan Gou, Wei Zhang, Wei Zhang, Lele Wang, Lele Wang, Caixia Tan, Caixia Tan, Hong Wei, Hong Wei, Xinmin Wang, Xinmin Wang, Le Zhang, Le Zhang, Le Zhang   +14 more
doaj   +1 more source

THE INCIDENCE OF TUBERCULOSIS. [PDF]

The Lancet, 1911
n ...
openaire   +2 more sources

Tunable high-energy ion source via oblique laser pulse incidence on a double-layer target

, 2007
The laser-driven acceleration of high quality proton beams from a double-layer target, comprised of a high-Z ion layer and a thin disk of hydrogen, is investigated with three-dimensional particle-in-cell simulations in the case of oblique incidence of a ...
A. V. Gurevich, C. K. Birdsall, J. Koga, M. Borghesi, M. Yamagiwa, S. V. Bulanov, T. Morita, T. Zh. Esirkepov, V. F. D’yachenko, V. I. Veksler   +9 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway

Parasites & Vectors, 2019
Background Larvae of Echinococcus granulosus (sensu lato) dwell in host organs for a long time but elicit only a mild inflammatory response, which indicates that the resolution of host inflammation is necessary for parasite survival.
Hui Wang, Chuan-Shan Zhang, Bin-Bin Fang, Zhi-De Li, Liang Li, Xiao-Juan Bi, Wen-Ding Li, Ning Zhang, Ren-Yong Lin, Hao Wen   +9 more
doaj   +1 more source

Benefit incidence analysis in Armenia [PDF]

, 2006
Shoghik ...
Hovhannisyan, Shoghik
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source