Results 81 to 90 of about 678,195 (314)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Monitoring of Incident Response Management Performance

, 2006
Monitoring the performance of incident response (IR) management is important input for improving the IR management system. A set of performance indicators, which assists monitoring in a proper way, is described regarding: the incident response management
Johnsen, Stig Ole, Albrechtsen, Eirik, Longva, Odd Helge, Hillen, Stefanie, Line, Maria B.   +4 more
core  

Incident duration modelling and system optimal traffic re-routing

, 2017
Traffic incidents are among the most significant contributory factors to congestion, particularly in metropolitan areas. In this dissertation, we have developed state-of-the-art statistical models to provide in-depth insights into how various incident ...
Tajtehranifard, Hasti
core   +1 more source

A novel tool for organisational learning and its impact on safety culture in a hospital dispensary [PDF]

, 2012
Incident reporting as a key mechanism for organisational learning and the establishment of a stronger safety culture are pillars of the current patient safety movement.
Sujan, Mark-Alexander
core   +1 more source

Correction to: Morbidity and mortality outcomes of COVID-19 patients with and without hypertension in Lagos, Nigeria: a retrospective cohort study

Global Health Research and Policy, 2021
Akin Abayomi, Akin Osibogun, Oluchi Kanma-Okafor, Jide Idris, Abimbola Bowale, Ololade Wright, Bisola Adebayo, Mobolanle Balogun, Segun Ogboye, Remi Adeseun, Ismael Abdus-Salam, Bamidele Mutiu, Babatunde Saka, Dayo Lajide, Sam Yenyi, Rotimi Agbolagorite, Oluwatosin Onasanya, Eniola Erinosho, Joshua Obasanya, Olu Adejumo, Sunday Adesola, Yewande Oshodi, Iorhen E. Akase, Shina Ogunbiyi, Adenike Omosun, Femi Erinoso, Hussein Abdur-Razzaq, Nike Osa, Kingsley Akinroye   +28 more
doaj   +1 more source

DNA Methylation Algorithms of Aging and Incident Cardiovascular Disease: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background While DNA methylation (DNAm)‐based algorithms of aging show promise for predicting age‐related diseases, their comparative utility for incident cardiovascular disease (CVD) remains underexplored.
Xian Cui, Chunbei Yi, Hui Zhang, Yaqian Xu, Chongyu Ding, Zhaojun Wang, Shiqun Sun, Xiangwei Li   +7 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Operational Failures and Problem Solving: An Empirical Study of Incident Reporting [PDF]

Operational failures occur in all industries with consequences that range from minor inconveniences to major catastrophes. Many organizations have implemented incident reporting systems to highlight actual and potential operational failures in order to ...
Julia Adler-Milstein, Michael W. Toffel, Sara J. Singer   +2 more
core  

Continuity of Operations in Newborn Screening: Lessons Learned from Three Incidents

International Journal of Neonatal Screening
Three incidents that impacted two US newborn screening (NBS) programs highlight the importance of contingency planning for the continuity of operations (COOP).
M. Christine Dorley, Elizabeth Bair, Patricia Ryland, Amanda D. Ingram, Emily Reeves, Kara J. Levinson, Ona O. Adair, Jenny F. Meredith, Susanne Crowe   +8 more
doaj   +1 more source