Results 91 to 100 of about 7,567,261 (256)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Managing Incidental Findings Conference: "Do Researchers Have a Duty of Care Regarding Incidental Findings?"

, 2007
On Tuesday, May 1, 2007, the Consortium on Law and Values hosted the "Managing Incidental Findings in Human Subjects Research: From Imaging to Genomics" conference.
Consortium on Law and Values in Health, Environment, & the Life Sciences
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Managing Incidental Findings Conference: "Empirical Findings"

, 2007
On Tuesday, May 1, 2007, the Consortium on Law and Values hosted the "Managing Incidental Findings in Human Subjects Research: From Imaging to Genomics" conference.
Consortium on Law and Values in Health, Environment, & the Life Sciences
core  

Biomedical research: incidental and unexpected findings. Classification and management

, 2014
Note from the Ethics committee. "Incidental and Unexpected Research Findings" Group.
Moutel, Grégoire, Eisinger, François, Daegelen, Dominique, Lapointe, Anne-Sophie, Brodin, Marc   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Rate of incidental findings on routine preoperative computed tomography for shoulder arthroplasty [PDF]

Clinics in Shoulder and Elbow
Background Incidental findings are commonly noted in advanced imaging studies. Few data exist regarding the rate of incidental findings on computed tomography (CT) for preoperative shoulder arthroplasty planning. This study aims to identify the incidence
Daniel G. Meeker, Maria F. Bozoghlian, Taylor Den Hartog, Jill Corlette, James V. Nepola, Brendan M. Patterson   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Incidental pathological findings in panoramic radiographs: An institution-based study

Saudi Journal for Health Sciences
Background: Panoramic radiography or orthopantomography is a widely used extraoral imaging technique that offers a comprehensive visualization of the maxillofacial complex and aids in detecting pathologies.
Sunila Thomas, Anchitha Elsa Shaji, Jincy Thomas, Shiana Jo, Shabna Fathima   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source