Results 111 to 120 of about 7,567,261 (256)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Prevalence and Clinical Relevance of Extracardiac Findings on Preprocedural Computed Tomography Angiography for Catheter Ablation of Atrial Fibrillation

Kardiyovasküler Tıp E Dergisi/E Journal of Cardiovascular Medicine
Objectives: Atrial fibrillation (AF), a common cardiac arrhythmia with significant stroke risk, is expected to increase in prevalence with an ageing population.
Reşit Yiğit Yılancıoğlu, Mahmut Mustafa Barış, Emin Evren Özcan   +2 more
doaj   +1 more source

Number and prevalence intracranial findings stratified into total number of findings, participants with findings, distribution of findings between men and women, total incidental findings, and number of individuals with incidental findings with clinical impact in the HUNT-MRI cohort of 1006 participants (476 men and 530 women).

, 2016
Number and prevalence intracranial findings stratified into total number of findings, participants with findings, distribution of findings between men and women, total incidental findings, and number of individuals with incidental findings with clinical ...
Live Eikenes (3181593), Mari Gårseth (3181596), Lars Jacob Stovner (81312), Tommy Arild Hammer (3181581), Kjell Arne Kvistad (3181587), Asta Kristine Håberg (3181584), Tomm B. Müller (3181590), Jana Rydland (3181578)   +7 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Incidental findings in surveillence of paediatric Li Fraumeni patients - A single centre experience [PDF]

Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome. Patients with LFS are at increased risk of early-onset tumours and undergo intensive radiological imaging surveillance to improve the early identification of malignancies.
Adams, Madeleine, McVittie, Elizabeth, Conti, Hector, Alcock, Amy, Davies, Mark, Nicholls, Zoe, Isaac, Rhian   +6 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Incidental findings during follow-up scans in oncological patients

, 2018
Background and aim. To assess the prevalence of incidental findings during follow-up scans of patients with oncologic pathology.Methods. 499 follow-up scans from different patients with cancer pathology were retrospectively analyzed.
Anamaria Pop, Claudia Militaru, Cosmin Caraiani, Adriana Calin, Lidia Ciobanu, Alexandra Berghe, Radu Badea   +6 more
core   +1 more source