Results 121 to 130 of about 291,670 (308)
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention
Nature Reviews. Cancer, 2022 S. Hecht, D. Hatsukami
semanticscholar +1 more source
Prevalence of exposure to occupational carcinogens among farmers.
Rural and remote health, 2018 INTRODUCTION Farmers experience a range of carcinogenic exposures, including some pesticides, fuels, engine exhausts, metals, some organic solvents, silica, wood dusts and solar radiation.
Ellie Darcey +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin +7 more
wiley +1 more source
Quality in SportCancer is a disease of genetic material and develops as a result of the accumulation of gradually occurring genetic damage. The transformation of a normal cell into a cancer cell, known as neoplastic transformation, requires several gene mutations.
Maria Ciechacka
doaj +1 more source
Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran [PDF]
, 2009 We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world.
Biramijamal, F. +4 more
core +3 more sources
Oxidative stress marker in oral cancer: A review.
Journal of Cancer Research and Therapeutics, 2016 Oxygen derived species such as hydrogen peroxide, superoxide anion radical, hydroxyl radical (OH-), and singlet oxygen are well known to be cytotoxic and have been implicated in the etiology of a wide array of human diseases, including cancer.
Payal Katakwar +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun +15 more
wiley +1 more source
Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility
Cadernos de Saúde PúblicaEpidemiological studies have estimated that approximately 80% of all cancers are related to environmental factors. Individual cancer susceptibility can be the result of several host factors, including differences in metabolism, DNA repair, altered ...
Ana Hatagima
doaj +2 more sources
Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer
Cancers, 2017 Lung cancer is the leading cause of deaths resulting from cancer owing to late diagnosis and limited treatment intervention. MicroRNAs are short, non-coding RNA molecules that regulate gene expression post-transcriptionally by translational repression or
K. Inamura
semanticscholar +1 more source
NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA
Advanced Science, EarlyView.MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen +13 more
wiley +1 more source