Results 101 to 110 of about 4,065,835 (293)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Challenges and Adaptation Strategies of Service Providers of Occupational Rehabilitation in Germany – Results of a Mixed Method Analysis

Safety and Health at Work, 2022
Anton Nivorozhkin, Angela Rauch, Nancy Reims   +2 more
doaj   +1 more source

MMSE–CDR‐SB residual as an exploratory indicator of deviation from an Alzheimer's disease–typical cognitive–functional pattern

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION In clinical practice, patients with Alzheimer's disease (AD) often present with cognitive and functional profiles that diverge from what is expected.
Ambre Mounié, Kenichiro Sato, Saki Nakashima, Masanori Kurihara, Ryoko Ihara, Yoshiki Niimi, Atsushi Iwata, Takeshi Iwatsubo   +7 more
doaj   +1 more source

Superiority and cost-effectiveness of Individual Placement and Support versus standard employment support for people with alcohol and drug dependence: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trialResearch in context

EClinicalMedicine
Summary: Background: Individual Placement and Support (IPS) is a specialist intervention to help people attain employment in the open competitive labour market. IPS has been developed in severe mental illness and other disabilities, but it is of unknown
John Marsden, Paul Anders, Claire Shaw, Chioma Amasiatu, Winnie Collate, Brian Eastwood, Patrick Horgan, Meetal Khetani, Jonathan Knight, Sandy Knight, Alexandra Melaugh, Helen Clark, Jez Stannard   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Understanding Inclusion [PDF]

, 2020
A guide for SENCOs, school leaders (including governors), teachers and support staff. This guide aims to: - Consider your position with regard to inclusion in your setting - Identify how you can develop an inclusive ethos and practice - Reflect on ...
Wharton, Julie, Middleton, Tristan, Codina, Geraldene, Esposito, Rosanne, Codina, G, Esposito, Roseanne   +5 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Vocational peer support for people with serious mental illness: a scoping review on mechanisms, structures, lived experience and perceived impacts

Humanities & Social Sciences Communications
People with serious mental illness face multiple barriers to (re-)entering the workforce, including early exclusion from the labor market, stigmatization, mental health instability, and fragmented support systems.
Franziska Günther-Sporns, Lena Hünefeld   +1 more
doaj   +1 more source