Results 181 to 190 of about 9,692,082 (341)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Preparing Students to Care for Socially Excluded Patients: A Qualitative Study of Inclusion Health in Undergraduate Medical Education. [PDF]

Clin Teach
Ashwell G, Russell AM, Pope L, Williamson A.   +3 more
europepmc   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Use of artificial intelligence to enhance social inclusion in mental health care: promises and pitfalls. [PDF]

World Psychiatry
Tse S.
europepmc   +1 more source

Equity, Inclusion and Conflict in Community Based Forest Management: A Case of Salghari Community Forest in Nepal

, 2015
Sushant Acharya, Bishnu Raj Upreti
openalex   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Social inclusion among young adults with mental illness and complex needs in Flexible Assertive Community Treatment: A qualitative study on team staff's understanding and experiences. [PDF]

PLoS One
Nord-Baade S, Ness O, Rowe M, Jensen CB, Landheim A.   +4 more
europepmc   +1 more source

Toward Exhilarating Classrooms: Representation vs. Inclusion in Japanese Language Education

, 2020
Arthur M. Mitchell
openalex   +2 more sources

Les « politiques inclusives ». Inclusion scolaire, inclusion et handicap

Travail et formation, 2014
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source