State-of-the-art and novel approaches to mild solubilization of inclusion bodies [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Throughout the twenty-first century, the view on inclusion bodies (IBs) has shifted from undesired by-products towards a targeted production strategy for recombinant proteins.
Robert Klausser +11 more
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Morphogenesis and functional organization of viral inclusion bodies [PDF]
Cell Insight, 2023 Eukaryotic viruses are obligate intracellular parasites that rely on the host cell machinery to carry out their replication cycle. This complex process involves a series of steps, starting with virus entry, followed by genome replication, and ending with
Zhifei Li +4 more
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Two Cases of Feather Dystrophy in Free-Living Griffon Vultures (Gyps fulvus fulvus) Associated with Viral-like Inclusion Bodies [PDF]
AnimalsThe griffon vulture (Gyps fulvus fulvus) is a scavenger species that plays a vital ecological role in carrion removal. Successful survival and reproduction in captive and wildlife conditions require optimal physical status and plumage integrity ...
Stefano Pesaro +12 more
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids [PDF]
eLifeDue to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs).
Xiuling Cao +9 more
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A compendium of specific histopathological bodies in dermatology
Indian Journal of Dermatology, 2021 The spectrum of histopathological variations of most of the Dermatological conditions is so wide and overlapping that even with our current vast knowledge of this discipline, it seems to be a tough task for clinicians as well as Dermatopathologists to ...
Anup Kumar Tiwary +3 more
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Inclusion Bodies in Ionic Liquids
Liquids, 2023 The pivotal role of proteins in pharmaceuticals is challenged by stability issues, making the study of inclusion bodies—a source of insoluble protein aggregates—increasingly relevant.
András Szabadi +3 more
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Bacterial inclusion bodies contain amyloid-like structure. [PDF]
PLoS Biology, 2008 Protein aggregation is a process in which identical proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally classified as amorphous, lacking any long-range order, or highly ordered fibrils. Protein fibrils can
Lei Wang +4 more
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Coiled-coil inspired functional inclusion bodies
Microbial Cell Factories, 2020 Background Recombinant protein expression in bacteria often leads to the formation of intracellular insoluble protein deposits, a major bottleneck for the production of soluble and active products.
Marcos Gil-Garcia +2 more
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Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein
Frontiers in Microbiology, 2020 High level expression of recombinant proteins in bacteria often results in their aggregation into inclusion bodies. Formation of inclusion bodies poses a major bottleneck in high-throughput recovery of recombinant protein.
Anupam Singh +3 more
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Kinetics of inclusion body formation and its correlation with the characteristics of protein aggregates in Escherichia coli. [PDF]
PLoS ONE, 2012 The objective of the research was to understand the structural determinants governing protein aggregation into inclusion bodies during expression of recombinant proteins in Escherichia coli.
Arun K Upadhyay +3 more
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