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Schaumann bodies: The basophilic inclusion body
Schaumann bodies are the inclusion bodies usually seen in sarcoidosis, but can also be found in other conditions like tuberculosis, chronic beryllium diseases and Crohn’s diseases. Histopathologically, these bodies appear as round to oval shell-like basophilic calcifications usually considered to be as a residuum of lysosomal organelles activity.
Jain, Ankush P. +3 more
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Inclusion Bodies in Trachoma [PDF]
THE epithelial-cell inclusion, which is characteristically found in the early stages of trachoma was first described by Halberstaedter and Prowazek (1907). Since that time, a considerable literature concerning the nature of these bodies has accumulated.
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The Biological Potential Hidden in Inclusion Bodies
Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein delivery.
Laia Gifre-Renom +13 more
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Microbial enzymes are increasingly finding applications as therapeutics due to their targeted activity and minimal side effects. Serratiopeptidase, also known as a miracle enzyme, has already proved its potential as an anti-inflammatory, mucolytic ...
Pooja Doshi +6 more
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Artificial Inclusion Bodies for Clinical Development
Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow‐protein‐releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these protein materials ...
Julieta M. Sánchez +11 more
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The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems.
Julieta María Sánchez +10 more
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Pustulonodular cytomegalovirus infection
The cutaneous manifestations of cytomegalovirus (CMV) vary and may be difficult to identify histopathologically. Cutaneous CMV lesions are relatively rare and may be overlooked as infection usually presents in visceral organs, particularly the ...
Mona Deerwester +2 more
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Solubilization of inclusion bodies: insights from explainable machine learning approaches
We present explainable machine learning approaches for gaining deeper insights into the solubilization processes of inclusion bodies. The machine learning model with the highest prediction accuracy for the protein yield is further evaluated with regard ...
Cornelia Walther +12 more
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Genetics in inclusion body myositis [PDF]
Purpose of review To review the advances in our understanding of the genetics of inclusion body myositis (IBM) in the past year. Recent findings One large genetic association study focusing on immune-related genes in IBM has refined the association within the human leukocyte antigen
Rothwell, Simon +2 more
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Isolation of cell-free bacterial inclusion bodies
Background Bacterial inclusion bodies are submicron protein clusters usually found in recombinant bacteria that have been traditionally considered as undesirable products from protein production processes.
Rodríguez-Carmona Escarlata +4 more
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