Results 41 to 50 of about 1,278,840 (295)
Pharmaceutics, 2022 The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems.
Julieta María Sánchez +10 more
doaj +1 more source
Pustulonodular cytomegalovirus infection
Human Pathology: Case Reports, 2020 The cutaneous manifestations of cytomegalovirus (CMV) vary and may be difficult to identify histopathologically. Cutaneous CMV lesions are relatively rare and may be overlooked as infection usually presents in visceral organs, particularly the ...
Mona Deerwester +2 more
doaj +1 more source
Solubilization of inclusion bodies: insights from explainable machine learning approaches
Frontiers in Chemical Engineering, 2023 We present explainable machine learning approaches for gaining deeper insights into the solubilization processes of inclusion bodies. The machine learning model with the highest prediction accuracy for the protein yield is further evaluated with regard ...
Cornelia Walther +12 more
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Isolation of cell-free bacterial inclusion bodies
Microbial Cell Factories, 2010 Background Bacterial inclusion bodies are submicron protein clusters usually found in recombinant bacteria that have been traditionally considered as undesirable products from protein production processes.
Rodríguez-Carmona Escarlata +4 more
doaj +1 more source
Yeast prions form infectious amyloid inclusion bodies in bacteria [PDF]
, 2012 Background: Prions were first identified as infectious proteins associated with fatal brain diseases in mammals. However, fungal prions behave as epigenetic regulators that can alter a range of cellular processes.
Espargaró Colomé, Alba +3 more
core +3 more sources
Microbial Cell Factories, 2018 Background Physiological aggregation of a recombinant enzyme into enzymatically active inclusion bodies could be an excellent strategy to obtain immobilized enzymes for industrial biotransformation processes.
Romana Koszagova +7 more
doaj +1 more source
Tailoring the properties of (catalytically)-active inclusion bodies
Microbial Cell Factories, 2019 Background Immobilization is an appropriate tool to ease the handling and recycling of enzymes in biocatalytic processes and to increase their stability. Most of the established immobilization methods require case-to-case optimization, which is laborious
V. D. Jäger +13 more
doaj +1 more source
Hereditary inclusion-body myopathies
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015 The term hereditary inclusion-body myopathies (HIBMs) defines a group of rare muscle disorders with autosomal recessive or dominant inheritance and presence of muscle fibers with rimmed vacuoles and collection of cytoplasmic or nuclear 15-21 nm diameter tubulofilaments as revealed by muscle biopsy.
Broccolini, Aldobrando +1 more
openaire +3 more sources
Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors [PDF]
, 2012 Background: The amyloid-β peptide (Aβ42) is the main component of the inter-neuronal amyloid plaques characteristic of Alzheimer's disease (AD). The mechanism by which Aβ42 and other amyloid peptides assemble into insoluble neurotoxic deposits is still ...
Espargaró Colomé, Alba +4 more
core +4 more sources
Engineering inclusion bodies for non denaturing extraction of functional proteins [PDF]
, 2008 Background For a long time IBs were considered to be inactive deposits of accumulated target proteins. In our previous studies, we discovered IBs containing a high percentage of correctly folded protein that can be extracted under non-denaturing ...
Špela Peternel +3 more
core +1 more source