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Identification of distinct immune signatures in inclusion body myositis by peripheral blood immunophenotyping using machine learning models. [PDF]
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Current Opinion in Neurology, 1999
Sporadic inclusion body myositis is a severely disabling muscle disease that mainly affects elderly individuals. The typical distribution of muscle weakness, poor response to immunosuppressive treatment, pathological accumulation of various proteins in vacuolated muscle fibres, inflammatory reaction and mitochondrial changes have all been subjects of ...
A, Oldfors, C, Lindberg
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Sporadic inclusion body myositis is a severely disabling muscle disease that mainly affects elderly individuals. The typical distribution of muscle weakness, poor response to immunosuppressive treatment, pathological accumulation of various proteins in vacuolated muscle fibres, inflammatory reaction and mitochondrial changes have all been subjects of ...
A, Oldfors, C, Lindberg
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Continuum, 2022
This article highlights the clinical and diagnostic features of inclusion body myositis (IBM) and provides recent insights into the pathomechanisms and therapeutic strategies of the disease.IBM is an often-misdiagnosed myopathy subtype. Due to the insidious onset and slow progression of muscle weakness, it can often be dismissed as a sign of aging as ...
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This article highlights the clinical and diagnostic features of inclusion body myositis (IBM) and provides recent insights into the pathomechanisms and therapeutic strategies of the disease.IBM is an often-misdiagnosed myopathy subtype. Due to the insidious onset and slow progression of muscle weakness, it can often be dismissed as a sign of aging as ...
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Neurology, 2006
Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei.
Valerie Askanas +2 more
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Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei.
Valerie Askanas +2 more
+4 more sources
Rheumatic Disease Clinics of North America, 1994
IBM remains a poorly understood form of idiopathic inflammatory myopathy, although great progress in the areas of clinical recognition and pathophysiology have been made recently. The question of whether therapy can favorably influence short- and/or long-term outcome is still unanswered.
L H, Calabrese, S M, Chou
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IBM remains a poorly understood form of idiopathic inflammatory myopathy, although great progress in the areas of clinical recognition and pathophysiology have been made recently. The question of whether therapy can favorably influence short- and/or long-term outcome is still unanswered.
L H, Calabrese, S M, Chou
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Current Treatment Options in Neurology, 2000
Inclusion body myositis (IBM) is usually refractory to immunosuppressive therapy; however, a few reports suggest that a minority of patients with IBM may have a partial, transient response or that therapy may slow progression. Therefore, although we generally discourage the use of immunosuppressive therapy for IBM, if the patient is willing to accept ...
, Barohn, , Amato
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Inclusion body myositis (IBM) is usually refractory to immunosuppressive therapy; however, a few reports suggest that a minority of patients with IBM may have a partial, transient response or that therapy may slow progression. Therefore, although we generally discourage the use of immunosuppressive therapy for IBM, if the patient is willing to accept ...
, Barohn, , Amato
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Current Opinion in Rheumatology, 2014
To examine new developments in sporadic inclusion body myositis (IBM), including updated clinical and prognostic factors, novel autoantibody associations, unique histopathologic findings, proposed new clinical diagnostic criteria, and novel therapeutic agents.IBM is a slowly progressive disease, leading to wheelchair use, on average, 12-20 years after ...
Arash H, Lahouti +2 more
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To examine new developments in sporadic inclusion body myositis (IBM), including updated clinical and prognostic factors, novel autoantibody associations, unique histopathologic findings, proposed new clinical diagnostic criteria, and novel therapeutic agents.IBM is a slowly progressive disease, leading to wheelchair use, on average, 12-20 years after ...
Arash H, Lahouti +2 more
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American Journal of Physical Medicine & Rehabilitation, 1990
Inclusion body myositis is a rare and slowly progressive myositis associated with cytoplasmic inclusions and fibrillar nuclear material. These histopathologic findings are of unknown significance. The clinical presentation of IBM has marked similarities to that of chronic polymyositis with proximal greater than distal weakness and muscle wasting more ...
D, Dumitru, M, Newell-Eggert
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Inclusion body myositis is a rare and slowly progressive myositis associated with cytoplasmic inclusions and fibrillar nuclear material. These histopathologic findings are of unknown significance. The clinical presentation of IBM has marked similarities to that of chronic polymyositis with proximal greater than distal weakness and muscle wasting more ...
D, Dumitru, M, Newell-Eggert
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Tubuloreticular inclusions in inclusion body myositis
Clinical Neuropathology, 2010To evaluate whether patients with inclusion body myositis (IBM) can have tubuloreticular inclusions present in muscle endothelial cells.Light microscopy with histochemical staining and electron microscopy of a right quadriceps muscle biopsy were used to identify the pathological features in an 83-year-old patient with a clinical diagnosis of IBM.Light ...
H D, Katzberg, D G, Munoz
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1981
The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter
F M, Tomé +3 more
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The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter
F M, Tomé +3 more
openaire +2 more sources