Results 161 to 170 of about 8,071 (195)
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Pathogenesis of inclusion body myositis
Current Opinion in Rheumatology, 2020Purpose of review To review the pathogenesis of inclusion body myositis (IBM). Recent findings IBM is an autoimmune disease. Multiple arms of the immune system are activated, but a direct attack on muscle fibers by highly differentiated T cells drives muscle destruction.
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Spectrum of Inclusion Body Myositis
Archives of Neurology, 1987The clinical, laboratory, and biopsy features are described for a large group of patients with inclusion body myositis (IBM) (15 men and four women; mean age, 63 years). A quantitative histopathologic analysis of muscle biopsy specimens revealed less fiber necrosis and endomysial and perivascular inflammation in IBM than in polymyositis (PM) and ...
S P, Ringel +4 more
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Genetics of inclusion‐body myositis
Muscle & Nerve, 2007AbstractSporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness.
Needham, M. +2 more
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Inclusion body myositis and myopathies
Current Opinion in Neurology, 1997Sporadic inclusion body myositis is a frequent, acquired, adult-onset vacuolar myopathy affecting proximal and distal muscles with a distinct, easily identifiable clinical pattern. Although its primary cause is still unknown, autoimmune, viral, and degenerative processes, alone or in combination, are being considered.
K, Sivakumar, M C, Dalakas
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Inclusion body myositis: an update
Current Opinion in RheumatologyPurpose of review To review recent advances in our understanding of the epidemiology, pathophysiology, and management of inclusion body myositis (IBM). Recent findings Recent epidemiologic studies have highlighted the morbidity and mortality associated with IBM, including the impact
Nicolaas C, Anderson, Thomas E, Lloyd
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Update on Inclusion Body Myositis
Current Rheumatology Reports, 2018While sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease after age 50, the pathogenesis of this disease is still poorly understood. In this review, we discuss our current state of knowledge in sIBM and provide an update on our current understanding of its pathophysiology and management.Lines of evidence in support of an ...
Duaa, Jabari +3 more
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Biomarkers of inclusion body myositis
Current Opinion in Rheumatology, 2013Inclusion body myositis (IBM) is a poorly understood autoimmune and degenerative disorder of skeletal muscle. Here, pathophysiological and diagnostic biomarkers of IBM are reviewed.Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiology for over three decades.
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Neurology, 1997
Because electrophysiologic, clinical, and histopathologic observations have suggested that inclusion body myositis (IBM) may have a coexistent neurogenic component, we used macro-electromyography (macro-EMG) to search for changes in the motor unit territory and signs of reinnervation. We studied 11 patients, aged 53 to 77 years (mean, 65.2 years), with
C A, Luciano, M C, Dalakas
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Because electrophysiologic, clinical, and histopathologic observations have suggested that inclusion body myositis (IBM) may have a coexistent neurogenic component, we used macro-electromyography (macro-EMG) to search for changes in the motor unit territory and signs of reinnervation. We studied 11 patients, aged 53 to 77 years (mean, 65.2 years), with
C A, Luciano, M C, Dalakas
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Treatment of inclusion body myositis
Current Opinion in Rheumatology, 1999Sporadic inclusion body myositis (s-IBM) is considered the most common muscle disease in patients older than 50 years, with a male predominance. Features of s-IBM include insidious onset, slowly and relentlessly progressive muscle weakness, a characteristic distribution and atrophy of both the proximal and distal muscle groups, and resistance to ...
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Neurology, 2006
Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei.
Valerie Askanas +2 more
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Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei.
Valerie Askanas +2 more
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