Results 151 to 160 of about 8,071 (195)
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Current Opinion in Neurology, 1999
Sporadic inclusion body myositis is a severely disabling muscle disease that mainly affects elderly individuals. The typical distribution of muscle weakness, poor response to immunosuppressive treatment, pathological accumulation of various proteins in vacuolated muscle fibres, inflammatory reaction and mitochondrial changes have all been subjects of ...
A, Oldfors, C, Lindberg
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Sporadic inclusion body myositis is a severely disabling muscle disease that mainly affects elderly individuals. The typical distribution of muscle weakness, poor response to immunosuppressive treatment, pathological accumulation of various proteins in vacuolated muscle fibres, inflammatory reaction and mitochondrial changes have all been subjects of ...
A, Oldfors, C, Lindberg
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Current Treatment Options in Neurology, 2000
Inclusion body myositis (IBM) is usually refractory to immunosuppressive therapy; however, a few reports suggest that a minority of patients with IBM may have a partial, transient response or that therapy may slow progression. Therefore, although we generally discourage the use of immunosuppressive therapy for IBM, if the patient is willing to accept ...
, Barohn, , Amato
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Inclusion body myositis (IBM) is usually refractory to immunosuppressive therapy; however, a few reports suggest that a minority of patients with IBM may have a partial, transient response or that therapy may slow progression. Therefore, although we generally discourage the use of immunosuppressive therapy for IBM, if the patient is willing to accept ...
, Barohn, , Amato
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Current Opinion in Rheumatology, 2014
To examine new developments in sporadic inclusion body myositis (IBM), including updated clinical and prognostic factors, novel autoantibody associations, unique histopathologic findings, proposed new clinical diagnostic criteria, and novel therapeutic agents.IBM is a slowly progressive disease, leading to wheelchair use, on average, 12-20 years after ...
Arash H, Lahouti +2 more
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To examine new developments in sporadic inclusion body myositis (IBM), including updated clinical and prognostic factors, novel autoantibody associations, unique histopathologic findings, proposed new clinical diagnostic criteria, and novel therapeutic agents.IBM is a slowly progressive disease, leading to wheelchair use, on average, 12-20 years after ...
Arash H, Lahouti +2 more
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Tubuloreticular inclusions in inclusion body myositis
Clinical Neuropathology, 2010To evaluate whether patients with inclusion body myositis (IBM) can have tubuloreticular inclusions present in muscle endothelial cells.Light microscopy with histochemical staining and electron microscopy of a right quadriceps muscle biopsy were used to identify the pathological features in an 83-year-old patient with a clinical diagnosis of IBM.Light ...
H D, Katzberg, D G, Munoz
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American Journal of Physical Medicine & Rehabilitation, 1990
Inclusion body myositis is a rare and slowly progressive myositis associated with cytoplasmic inclusions and fibrillar nuclear material. These histopathologic findings are of unknown significance. The clinical presentation of IBM has marked similarities to that of chronic polymyositis with proximal greater than distal weakness and muscle wasting more ...
D, Dumitru, M, Newell-Eggert
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Inclusion body myositis is a rare and slowly progressive myositis associated with cytoplasmic inclusions and fibrillar nuclear material. These histopathologic findings are of unknown significance. The clinical presentation of IBM has marked similarities to that of chronic polymyositis with proximal greater than distal weakness and muscle wasting more ...
D, Dumitru, M, Newell-Eggert
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1981
The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter
F M, Tomé +3 more
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The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter
F M, Tomé +3 more
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Inclusion body myositis and paramyxoviruses
Human Pathology, 1991Inclusion body myositis (IBM) is a distinct type of muscle disease. The characteristic electron microscopic findings, intranuclear or intracytoplasmic inclusions composed of microtubular filaments, morphologically resemble paramyxovirus nucleocapsids.
M, Kallajoki +5 more
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Inclusion body myositis and myopathies
Annals of Neurology, 1995Preface Part I. Overview of Pathologic and Pathogenic Comparison Between Sporadic Inclusion-Body Myositis and Hereditary Inclusion-Body Myopathies: 1. Newest approaches to diagnosis and pathogenesis of sporadic inclusion-body myositis and hereditary inclusion-body myopathies, including molecular-pathologic similarities to Alzheimer disease Part II ...
R C, Griggs +6 more
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2007
Publisher Summary This chapter discusses inclusion body myositis (IBM). It is usually a slowly progressive myopathy that causes considerable morbidity but does not directly cause mortality. The lack of any effective treatments makes it a challenge to manage.
Michael R, Rose, Robert C, Griggs
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Publisher Summary This chapter discusses inclusion body myositis (IBM). It is usually a slowly progressive myopathy that causes considerable morbidity but does not directly cause mortality. The lack of any effective treatments makes it a challenge to manage.
Michael R, Rose, Robert C, Griggs
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Inclusion body myositis in twins
Neurology, 1998Sporadic inclusion body myositis (s-IBM) is characterized by late onset of slowly progressive weakness that involves the quadriceps and volar forearm muscles early in the course of the disease. There are hereditary forms of inclusion body myopathy (h-IBM) that histologically resemble s-IBM.
A A, Amato, R T, Shebert
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