Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Growth and Development….. Inclusive Growth: What went wrong with Development?
This paper critically reviews the debate of ‘growth and development’ since 1950 in order to place and conceptualize the term inclusive growth. The paper argues that the basic objective of inclusive growth is the smooth functioning of nation state and to ...
George, Justine
core
Science Education for Inclusive Citizenship
This chapter emphasizes the role of critical and engaged inclusive science education in inclusive citizenship. It has the potential of empowering individuals to actively participate in social discourses and decision making.
Sjöström, Jesper,, Nehring, Andreas,
core +1 more source
Determining the Relationship Between People's Explicit and Implicit Preferences for Gender-Inclusive Sexual and Reproductive Health Content: Randomized Controlled Trial. [PDF]
Interact J Med ResBoskey ER +3 more
europepmc +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Using hope theory to understand changes from professional learning in inclusive education
Professional learning for quality teaching is a lifelong enterprise. Nevertheless, it entails a considerable cost with varying outcomes. Drawing on Snyder's hope theory and Pantic's teacher agency, this paper aims to present a model aimed at deepening ...
Carrington, Suzanne +4 more
core +1 more source
Algorithmic inclusion? The role of AI-assisted inclusive leadership in shaping gendered outcomes in multicultural academic teams. [PDF]
Front PsycholTahir I +4 more
europepmc +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source