Results 191 to 200 of about 702,644 (319)

Inclusive research: where does it leave people with PMLD?

open access: yes
A journal article for a practitioner audience in special issue celebrating 25 years of sharing sharing information in support of people with profound and multiple learning disabilities.
Nind, Melanie
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Inclusive Education: Global Issues and Controversies

open access: yes
"This edited book considers the main issues and controversies within the current educational context of inclusive education, from an international perspective.
Boyle, Christopher   +3 more
core  

Exploration of the quality of participation in an inclusive ultra-trail initiative for people with a disability: a qualitative ethnographic study. [PDF]

open access: yesFront Sports Act Living
Ouellet R   +7 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Interventions to Promote Inclusive Governance for Underserved Populations in Sub-Saharan Africa: An Evidence and Gap Map. [PDF]

open access: yesCampbell Syst Rev
Nyan CP   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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