Results 61 to 70 of about 20,060 (257)

Global Financial Architecture Reform and the Role of the Global South [PDF]

Međunarodna politika
The existing global financial architecture is increasingly revealing structural flaws in addressing multiple systemic crises, with issues such as dollar hegemony, governance inequity, inadequate representation, and a lack of development orientation ...
Xu Xuemei
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Inclusive Architecture for Individuals with Visual Impairments: A Study of Pacelli School for the Blind and Partially Sighted in Surulere, Lagos, Nigeria

Journal of Engineering
This research on architecture examines the challenges faced by individuals with visual impairments as they navigate schools and other built environments.
Bolawole Ogunbodede, Segun Okunola, Akinfolarin Jobi, Jesufolahanmi Oyedeji   +3 more
doaj   +1 more source

Giancarlo De Carlo’s Concept of Architecture – a Powerful and Inclusive Tool for Thinking about Educational Space

Histories of Postwar Architecture, 2020
This paper explores Giancarlo De Carlo’s concept of architecture as discussed in his writing and argues that it offers a particularly inclusive way of thinking about educational space.
Adam Wood
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Completing the History of Spanish Architecture : The Female Contribution

Architectural Histories
A review of MuWo: Mujeres en la cultura arquitectónica (pos)moderna española, 1965–2000. The review traces the genesis of this research project, highlighting its main results so far and how they have been disseminated and emphasising the need for an ...
Zaida Garcia-Requejo
doaj   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Qualitative Description of Spatial Quality in Inclusive Architecture

, 2016
Universal design (UD) has gained global significance and is in the process of institutionalisation in the Nordic Region. This is despite an urgent necessity for developing the theoretical basis and practical applicability of UD. Reflecting this need for furthering the comprehensive understanding of spatial implication of UD, this paper aims to ...
Camilla Ryhl, Masashi Kajita, René Sørensen   +2 more
openaire   +3 more sources