Results 201 to 210 of about 1,250,319 (355)

Community-based, inclusive design of a 3D tactile map to enable playground navigation for children who are visually impaired and blind. [PDF]

J Rehabil Assist Technol Eng
Alturaifi A, Colbert J, Doakes L, Dupont K, Faulk B, Gatune E, Gaudet J, Gayle A, Jena S, Kennard G, Le T, Lima M, Maxwell I, Matherne C, Robinson JF, Tramontana B, Tran T, Vallery S.   +17 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Understanding quality in inclusive research: a process of dialogue

, 2013
The case for research by and with (rather than on) people with learning disabilities has been successfully made. Calls for emancipatory research have drawn attention to the ways that research owned by disabled people can better tackle social oppression ...
Nind, Melanie
core  

Ripple: a scalable, radically inclusive, and transdisciplinary approach for engaged design research on climate action [PDF]

Orla Murphy, Sarah Cotterill, Sawsan Bassalat, Philip Crowe   +3 more
openalex   +1 more source

Integration of Conversion Factors for the Development of an Inclusive eHealth Tool With Caregivers of Functionally Dependent Older Persons: Social Justice Design (Preprint)

, 2020
Karine Latulippe, Christine Hamel, Dominique Giroux   +2 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Development of an online service for coping with spousal loss by means of human-centered and stakeholder-inclusive design: the case of LEAVES. [PDF]

Death Stud
van Velsen L, Schokking L, Siderakis E, Knospe GM, Brandl L, Mooser B, Madörin S, Jacinto S, Gouveia A, Brodbeck J.   +9 more
europepmc   +1 more source

Consolidated Principles for Equitable and Inclusive Digital Health and Virtual Care Co-Design

Paula Voorheis, Jennifer Major, Jennifer Stinson, Ron Beleno, Colleen Ferris, Carolyn Steele Gray   +5 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Making the case for inclusive design

, 2013
Sam Waller, Mike Bradley, Ian Hosking, P. John Clarkson   +3 more
openalex   +2 more sources