Results 161 to 170 of about 307,576 (314)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Inclusive Environments: Designing a Framework for Environmental Justice (Full Report) [PDF]

This research builds on the report and recommendations of the Cheshire and Warrington Sustainable and Inclusive Growth Commission (SIGC) (2022) (Sustainable and Inclusive Growth Commission, 2022) .
Davies, Chantal, Ekhator, Eghosa, White, Holly, Ross, Kim   +3 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Inclusive Environments: Designing a Framework for Environmental Justice (Final Report) [PDF]

This research builds on the report and recommendations of the Cheshire and Warrington Sustainable and Inclusive Growth Commission (SIGC) (2022) (Sustainable and Inclusive Growth Commission, 2022).
White, H., Davies, C., Ekhator, E., Ross, K.   +3 more
core  

An Ubuntu approach to disability and inclusive development for women with disabilities. [PDF]

Afr J Disabil
Lorenzo T, Sefotho MM.
europepmc   +1 more source

Inclusive growth: A dataset on key and institutional foundations for inclusive development of Russian regions. [PDF]

Data Brief, 2019
Sharafutdinov RI, Akhmetshin EM, Polyakova AG, Gerasimov VO, Shpakova RN, Mikhailova MV.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Aspects of administrative support in implementing inclusive education : a case study of three finnish comprehensive schools

, 2014
Inclusive education is about all learners having a right to go to their local schools and receive support in learning there, instead of placing some learners in special schools and classrooms. It is a question of equality and human rights.
Kesälahti, Essi
core