Results 171 to 180 of about 6,115,741 (434)

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

open access: yesMolecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen   +6 more
wiley   +1 more source

Outcome-Based Quality Assessment Framework for Higher Education [PDF]

open access: yesarXiv, 2017
This research paper proposes a quality framework for higher education that evaluates the performance of institutions on the basis of performance of outgoing students. Literature was surveyed to evaluate existing quality frameworks and develop a framework that provides insights on an unexplored dimension of quality.
arxiv  

Education for all- Inclusive education [PDF]

open access: yes, 2013
Education for all is the slogan of UNESCO. During the last decades a worldwide movement towards inclusive education is taken place. The idea is to make the school accessible to all children, whatever their differences or background.
Grácio, Luísa   +3 more
core  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Inclusive Practices Outside of the United States: A Scoping Literature Review

open access: yesEducation Sciences
Regardless of differences in abilities, background, or citizenship, students have a right to effective education alongside their peers who do not have disabilities.
Eric J. Anderson   +2 more
doaj   +1 more source

Development of an Inclusive Educational Platform Using Open Technologies and Machine Learning: A Case Study on Accessibility Enhancement [PDF]

open access: yesarXiv
This study addresses the pressing challenge of educational inclusion for students with special needs by proposing and developing an inclusive educational platform. Integrating machine learning, natural language processing, and cross-platform interfaces, the platform features key functionalities such as speech recognition functionality to support voice ...
arxiv  

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