Results 181 to 190 of about 220,781 (280)

Incidence of syphilitic hepatitis among patients with neurosyphilis. [PDF]

Intern Med J
Sun J, Wang L, Pokorny C.
europepmc   +1 more source

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection

Advanced Science, EarlyView.
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez, David Azorín‐Soriano, Araceli Lérida‐Viso, Jessie García‐Fleitas, Paula M Soriano‐Teruel, Jennifer Soler Beatty, Paula Rodrigo‐Martínez, Pau Arroyo, Sara Rojas‐Vázquez, Isabel Fariñas, Félix Sancenón, Juan F. Blandez, Alba García‐Fernández, Ramón Martínez‐Máñez   +13 more
wiley   +1 more source

Dopaminergic manipulation modulates frequency-specific EEG connectivity patterns: evidence from a single dose drug challenge study. [PDF]

Front Neurosci
Preuss AJ, de Bock R, Mackintosh AJ, Schuster S, Sterzer P, Obleser J, Borgwardt S, Andreou C.   +7 more
europepmc   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Liver function indicators as risk factors of pediatric metabolic (dysfunction)-associated fatty liver disease: a systematic review and meta-analysis. [PDF]

Transl Pediatr
Fan X, Cheng F, Zhou H, Gou H.
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review. [PDF]

Transl Psychiatry
Dai Z, Jia M, Zhou H, Wang H.
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Risk factors for COVID-19 symptom severity across clinical categories among hospitalised patients in Kuala Lumpur, Malaysia: a prospective cohort study. [PDF]

BMJ Open
Johdi NA, Abdullah N, Goh YX, Min JOS, Muhammad Azami NA, Abdul Jalal MI, Mohammed Nawi A, Ahmad N, Hassan MR, Sulong A, Kori N, Periyasamy P, Hamid F, Sapuan NM, Selvam SBP, Hajib N, Mustafa N, Rashid NZZ, Salleh SA, Alias H, Mohamed Said MS, Othman SN, Koon PB, Hamzah FA, Jamal SM, Jarmin R, Othman H, Nawawi K, Harunarashid H, Mokhtar MN, Wan Mat WR, Kamalul Arifin AS, Khuzaimi AN, Abd Jalal N, Ismail N, Mhd Yusuf NA, Dauni A, Wan Sallam WAF, Shafie AS, Kamaruddin MA, Jamal R.   +40 more
europepmc   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source