Results 181 to 190 of about 45,544 (263)

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Mapping the Influence of Ansoff's Corporate Strategy

Strategic Change, EarlyView.
ABSTRACT This paper conducts a systematic, data‐driven analysis of H. Igor Ansoff's enduring impact on strategic management scholarship. Despite Ansoff's recognition as the “father of strategic management” and the continued relevance of his frameworks—including the Ansoff matrix, weak signals analysis, and strategic thrust—a comprehensive understanding
Ivan Zupic, Tomaž Čater, Andrea Caputo, Dejan Uršič   +3 more
wiley   +1 more source

Phytop: a tool for visualizing and recognizing signals of incomplete lineage sorting and hybridization using species trees output from ASTRAL. [PDF]

Hortic Res
Shang HY, Jia KH, Li NW, Zhou MJ, Yang H, Tian XL, Ma YP, Zhang RG.   +7 more
europepmc   +1 more source

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri, Neda Mohsen‐Pour, Najmeh Salehi, Pardis Ketabi Moghadam, Adel Zeinalpour, Amir Sadeghi, Samira Kalayinia, Nayeralsadat Fatemi   +7 more
wiley   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Phylogenomic Discordance is Driven by Wide-Spread Introgression and Incomplete Lineage Sorting During Rapid Species Diversification Within Rattlesnakes (Viperidae: Crotalus and Sistrurus). [PDF]

Syst Biol
Myers EA, Rautsaw RM, Borja M, Jones J, Grünwald CI, Holding ML, Grazziotin FG, Parkinson CL.   +7 more
europepmc   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Brownotate, a Comprehensive Solution to Generate Protein Sequence Databases for Any Species

PROTEOMICS, EarlyView.
ABSTRACT Proteomics is strengthening research in biology and the diversification of the model organisms studied is very promising for fully understanding the complexity of biological principles. However, the lack of protein sequence databases for many species is a major bottleneck.
Adrien Brown, Alexandre Burel, Sarah Cianférani, Christine Carapito, Fabrice Bertile   +4 more
wiley   +1 more source

An examination of introgression and incomplete lineage sorting among three closely related species of chocolate-dipped damselfish (genus: Chromis). [PDF]

Ecol Evol, 2019
He S, Robitzch V, Hobbs JA, Travers MJ, Lozano-Cortés D, Berumen ML, DiBattista JD.   +6 more
europepmc   +1 more source

Repositories of biocultural diversity: Toward best practices for empowering ethnobotany in digital herbaria

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement As herbaria digitize millions of plant specimens, ethnobotanical information associated with them is becoming increasingly accessible. These biocultural data include plant uses, names, and/or management practices of Indigenous Peoples and Local Communities (IPLCs).
Robbie Hart, Viviane Fonseca‐Kruel, Eduardo Dalcin, Estevão da Silva Luís Alexandre, Matthew Pace, Michaela Schmull, Leonardo Beltran‐Rodríguez, Miguel Murguía‐Romero, Diana G. Flores‐Camargo, Cristina Mapes‐Sánchez, Mark Nesbitt, Carolina Romero, Andrew Townesmith, Jan Salick, Alex McAlvay, Kenneth R. Otero‐Walker, Michael J. Balick, Jacob Golan, Bruce Hoffman, Kelsey Leonard, Giulia Mattalia, Guillaume Odonne, Aurora Prehn, Ina Vandebroek   +23 more
wiley   +1 more source