Results 31 to 40 of about 52,693 (244)

Incremental Quantitative Analysis on Dynamic Costs

, 2016
In quantitative program analysis, values are assigned to execution traces to represent a quality measure. Such analyses cover important applications, e.g. resource usage. Examining all traces is well known to be intractable and therefore traditional algorithms reason over an over-approximated set.
Chu, Duc-Hiep, Jaffar, Joxan, Murali, Vijayaraghavan   +2 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Proposed Fragility Curve Based on PO-ID Hybrid Analysis for Seismic Assessment Performance of the Reinforced Concrete Continuous Bridges in Earthquake Prone Area

Buildings
In earthquake-prone regions, the seismic performance assessment of reinforced concrete (RC) continuous bridges is critical for ensuring their resilience and safety.
Khin Thuzar Htay, Jafril Tanjung, Masrilayanti, Monita Olivia, Fadzli Mohamed Nazri, Mulyadi Bur   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Assessing Material Fragility using Nanoscale Incremental Dynamic Analysis [PDF]

, 2021
A new methodology to assess material failure subjected to stochastic loads is proposed, titled Nanoscale Incremental Dynamic Analysis (NIDA), which is adopted from performance-based assessment in structural engineering. Using full atomistic molecular dynamics, proof-of-concept simulations produce the material fragility curve of a simple carbon nanotube.
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

opseestools: A Python library to streamline OpenSeesPy workflows

SoftwareX
OpenSees, a framework for nonlinear structural analysis, has significantly advanced seismic research and practice. The introduction of OpenSeesPy in 2018, which integrated Python as an interpreter alongside TCL, greatly enhanced the framework's utility ...
Orlando Arroyo, Dirsa Feliciano, Daniela Novoa, Jairo Valcárcel   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Incremental Dynamic Analysis of Mid-Rise Buildings with Buckling Restrained Brace Frame System under Pulse-Like Near-Fault Ground Motions [PDF]

Journal of Rehabilitation in Civil Engineering
Buckling Restrained Braced Frames (BRBFs) are frequently utilized as seismic force-resisting systems due to their considerable ductility and energy dissipation capacity.
Yaghub Minaei, Mohammadreza Mashayekhi, Mohammad Sarcheshmehpour   +2 more
doaj   +1 more source