Results 241 to 250 of about 440,724 (260)

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

open access: yesAdvanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang   +7 more
wiley   +1 more source

4D Insights into Coral Biomineralization: Effects of Ocean Acidification on the Early Skeleton Development of a Stony Coral

open access: yesAdvanced Science, EarlyView.
Early coral skeletons grow through formation of two co‐joined zones, rapid accretion deposits and thickening deposits. Advanced imaging and simulations reveal that ocean acidification reshapes these zones, shifting the coral portfolio of mineral phases which alters skeletal resistance to mechanical stress.
Federica Scucchia   +4 more
wiley   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

open access: yesAdvanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen   +10 more
wiley   +1 more source

Flow with FlorDB: Incremental Context Maintenance for the Machine Learning Lifecycle [PDF]

open access: green
Rolando Garcia   +5 more
openalex   +1 more source

Artificial Tactile Perception System for Exploring Internal and External Features of Objects via Time‐Frequency Features

open access: yesAdvanced Science, EarlyView.
By engaging in different active exploration behaviors, the tactile perception system can generate distinct signal modes, enabling the application of targeted decoding strategies for efficient and accurate perception of both external and internal object features.
Yuanzhi Zhou   +8 more
wiley   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

open access: yesAdvanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha   +11 more
wiley   +1 more source

Automated Benchmarking of Variable‐Property Soft Robotic Fingertips to Enable Task‐Optimized Sensor Selection

open access: yesAdvanced Science, EarlyView.
Sensorized fingertips are needed to unlock robotic dexterity, versatility, and diverse interactions. Here, 15 identically‐shaped robotic fingertips are benchmarked by a fully automated toolchange system, covering eight different materials and six broadly‐ranging sensing mechanisms.
David Hardman   +5 more
wiley   +1 more source

A Three‐Phase Electrostatic Clutch with Variable Mechanical Impedance Control for Soft Robotic Systems

open access: yesAdvanced Science, EarlyView.
The research introduces a three‐phase electrostatic (ES) clutch with variable mechanical impedance control, specifically designed to enable continuous and precise friction modulation, thereby reducing both force degradation and oscillatory motion. This method effectively resolves conventional ES clutch issues, such as residual charge accumulation and ...
Dongyoung Lee, Heejin Yu, Joonbum Bae
wiley   +1 more source

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