Results 121 to 130 of about 216,250 (267)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Spontaneous granulation of tricaprin and trilaurin medium-chain triacylglycerols with added medium- and long-chain species

npj Science of Food
To utilize medium-chain triacylglycerol (MCT) with a low smoke point (~150 °C) in water, we investigated formulations and physical conditions for its spontaneous powdery crystallization without excipients. Crystallization of tricaprin and trilaurin mixed
Yutaro Kataoka, Hidetaka Uehara, Kentaro Matsumiya   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Blood metabolites as predictors to evaluate the body condition of Neopelma pallescens (Passeriformes: Pipridae) in northeastern Brazil

Zoologia (Curitiba)
Body condition is an important ecological attribute that can provide a measure of the energy stored by an animal or population. Body condition is traditionally ascertained with morphometric body condition indices (BCIs), but some researchers have used ...
Luane M.M. Azeredo, Talita C. Oliveira, Luiz C.S. Lopez   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Comprehensive Evaluation of a Hybrid Forward Osmosis - Reverse Osmosis System for Wastewater Treatment, Desalination, and Energy Recovery

Journal of Water and Environment Technology
Forward osmosis (FO) technology, though gaining interest in the last two decades, is still regarded as non-economically viable option. In the light of the recent advances in FO membrane technology and potential benefits of its integration with reverse ...
Mokhtar Guizani, Hideshi Nishimura, Fumio Muto, Shuichi Arai, Takao Murakami   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The Effect of Early Incubation Temperature and Late Incubation Conditions on Embryonic Development and Subsequent Broiler Performance.

, 2007
Six experiments were conducted to evaluate the effects of early and late incubation temperatures and hatching basket ventilation on embryonic development and early broiler performance.
Brannan, Kelly Elizabeth
core  

Latitudinal variation in day length and working day length has a confounding effect when comparing nest attentiveness in tropical and temperate species

, 2014
We gratefully acknowledge the financial support provided by the British Ornithologists’ Union and the African Bird Club.During incubation, tropical passerines have been shown to have lower levels of nest attentiveness than their counterparts at north ...
Cresswell, Will, Shaw, Philip
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source