Results 291 to 300 of about 2,629,038 (335)

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer. [PDF]

Elife
Morano L, Vezzio-Vié N, Aissanou A, Egger T, Aze A, Fiachetti S, Bordignon B, Hassen-Khodja C, Seitz H, Milazzo LA, Garambois V, Chaloin L, Bonnefoy N, Gongora C, Constantinou A, Basbous J.   +15 more
europepmc   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Evaluating DAPI stain to assess sperm membrane integrity by flow cytometry in livestock species. [PDF]

Vet Res Commun
Martínez-Rodrigo L, Gacem S, Brüggemann M, Pinto S, Mocé E, Serrano-Jara D, García ML, Yániz JL, Silvestre MA.   +8 more
europepmc   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Protease-Activated Receptor 2 Activation Provokes an Increase in Intracellular Calcium and Serotonin Secretion in a Human Enteroendocrine Cell Line. [PDF]

Cell Biochem Funct
Pfanzagl B, Jensen-Jarolim E.
europepmc   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Incubation with tau aggregates increases hippocampal circuit excitability and enhances long-term depression in acute mouse hippocampal slices. [PDF]

Front Neural Circuits
Wang A, Richardson A, Emmett I, Friedmann D, Bakker S, Richardson M, Hill E, Wall M.   +7 more
europepmc   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Mycobacterium farcinogenes-induced lymphadenitis in a pediatric patient: a case report. [PDF]

BMC Infect Dis
Liu X, Jiang Y, Liang L, Zhou W, Kuang L, Ling J, Wu W, Yan Z, Luo J.   +8 more
europepmc   +1 more source