Results 31 to 40 of about 436,071 (266)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Capacidade absortiva de empreendimentos incubados e as ações de inovação no contexto de agronegócios paraibanos / The absorptive capacity of incubated enterprises and innovation actions in the context of agribusiness in Paraíba, Brazil

RAM. Revista de Administração Mackenzie, 2022
Resumo Objetivo: Este artigo analisa a capacidade absortiva e as ações de inovação de empresas incubadas na Incubadora de Agronegócios das Cooperativas, Organizações Comunitárias, Associações e Assentamentos Rurais do Semiárido da Paraíba (Iacoc ...
Karina T. Lima, Leonardo F. Batista, Vinicius F. Moreira   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Three-Dimensional Imaging Sensor-Based Non-Contact Measurement of Neonatal Head Circumference in Incubators

Sensors
In Japan, birth rates are declining, but there are a rising number of underweight newborns who require specialized care in neonatal intensive care units (NICUs).
Khin Dagon Win, Kikuhito Kawasue, Masatoki Kaneko   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Exploring the feasibility of applying a conceptual model of soft systems methodology in implementing a management information system in Universities of Medical Sciences incubators [PDF]

Journal of Health Management & Informatics, 2020
Introduction: A management information system (MIS) can have a great effect on the effectiveness and efficiency of management in different centers. Various conceptual models are used for designing, implementing, and evaluating this system.
Nahal Aarabi, Rouhollah Tavallaee, Hashem Montaseri, AliReza Slambolchi   +3 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Evaluating the performance of Moroccan social incubators: an SFA analysis of youth platforms under the national initiative for human development

Business, Management and Economics Engineering
Purpose – This study focuses on the evaluation of youth platforms as an important  social incubator of the National Initiative for Human Development (NIHD) in Morocco, particularly to promote social entrepreneurship and support very small enterprises ...
Younes El Maaqili, Mariam Tlemcani Mhandez, Abdessamad Ouchen   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source