Results 71 to 80 of about 25,605 (265)
Archives of Disease in Childhood - Fetal and Neonatal Edition, 1994 DELLAGRAMMATICAS, HD, PAPAGEORGIOU, A
openaire +3 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Participación y apoyo a los emprendedores en el programa de incubación de empresas en Michoacán
Ciencias Administrativas Teoría y Praxis, 2018 Resumen Este artículo contempla el tema relacionado a los emprendedores y la incubación de empresas, que son parte de las categorías que destacaron de los resultados de la investigación Participación del Programa de Apoyo a Emprendedores en ...
Lucía de-la-Cueva García-Teruel
doaj
Tourism and Hospitality ManagementPurpose - This study investigates the impact of incubators on knowledge management and sustainable innovation in early-stage tourism and hospitality firms. It explores whether incubators leverage innovation generated by these firms. Methodology/Design/
Álvaro DIAS +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Management of Indonesia ICT Business Incubators: Administrators’ Compared to Tenants’ Perspecive
STIPM (STI Policy and Management) Journal, 2017 Business incubation is one of entrepreneurship development methods believed to have advantages compared with other SME development patterns. The model used in managing the business incubators is influenced by the business focus of the participants ...
Emyana Ruth Eritha Sirait, Faiq Wildana
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
International Journal of Innovation, 2018 The objectives of the present study were to investigate the current ecosystem of innovative entrepreneurship in the state of Goiás, Brazil, and provide an overview of its incubators, identifying connections and interactions between these mechanisms and ...
Bruno Alencar Pereira +3 more
doaj +1 more source