Results 41 to 50 of about 2,004 (114)

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, Volume 27, Issue 6, Page 994-1002, June 2025.
Among high‐risk patients with type 2 diabetes, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. CI, confidence interval; CKD, chronic kidney disease; CV, cardiovascular; HF, heart failure; HR, hazard ratio ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source

INOVAÇÕES NA INDÚSTRIA FARMACÊUTICA - ESTUDO DE UMA INDÚSTRIA DE MEDICAMENTOS GENÉRICOS

Caderno de Administração, 2017
Uma característica importante para definir a indústria farmacêutica são os altos investimentos em pesquisa, desenvolvimento e inovação (PD&I), em parceria com outras instituições, o que possibilitou um ritmo alto de inovações desenvolvidas nos últimos ...
Maira UEZ, Fabiano DAMIN, Moises Ari ZILBER   +2 more
doaj   +3 more sources

LA INDUSTRIA FARMACÉUTICA ESPAÑOLA: ANÁLISIS MEDIANTE LA PERSPECTIVA DE GRUPOS ESTRATÉGICOS 2000-2003

Revista Visión Gerencial, 2007
La industria farmacéutica española ha sufrido una importante transformación durante los últimos años. Para sobrevivir a estas nuevas condiciones de mercado, las empresas han redimensionado sus estrategias competitivas hacia actividades de Investigación ...
Enzo Piña
doaj  

Saúde, medicamentos, marketing e médicos

Revista Portuguesa de Medicina Geral e Familiar, 2008
O presente artigo introduz uma visão muito sintética da situação da Saúde em Portugal e do seu posicionamento em relação a outros países com um grau de desenvolvimento semelhante.
Luís Dos Santos Ferreira
doaj   +1 more source

Treatment and outcome of gall bladder leiomyoma in an asymptomatic dog

Veterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract The purpose of this report was to describe the diagnostic protocol, treatment and outcome of an 11‐year‐old, entire male, mixed‐breed dog with a gall bladder neoplasia histologically consistent with a leiomyoma. On referral, the patient had no clinical signs related to the gall bladder mass.
Elisa Pizzi, Stefano Zanardi, Andrea Renzi, Ilaria Maga, Sara Del Magno   +4 more
wiley   +1 more source

Expert opinion on gray areas in asthma management: A lesson from the innovative project “revolution in asthma” of the Italian thoracic society (AIPO‐ITS)

Clinical and Translational Allergy, Volume 15, Issue 2, February 2025.
Abstract Background Despite the availability of numerous guidelines for asthma management, their recommendations are not consistently implemented in clinical practice. This discrepancy between guidelines and real‐world practice among Italian healthcare professionals was explored during the “Revolution in Asthma” training program, which identified “gray
Adriano Vaghi, Raffaele Antonelli Incalzi, Simona Barbaglia, Maria Beatrice Bilò, Francesco Bini, Mauro Carone, Lorenzo Cecchi, Alfredo Antonio Chetta, Andrea Claudio Comel, Fausto De Michele, Giuseppe Insalaco, Antonino Musarra, Giovanni Pomponio, Antonio Spanevello, Silvia Tognella, Alessandro Vatrella, Lina Zuccatosta, Claudio Micheletto   +17 more
wiley   +1 more source

Medicamentos com defeitos estão entre nós! Umaanálise do combate aos defeitos em embalagens demedicamentos à luz do Direito Administrativo Sanitárioe do Consumidor

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia
Introdução: Disponibilizar medicamento com qualidade, seguro e eficaz é a finalidade da cadeia de produção e suprimento, entretanto, erros ocorrem.
Alexandre Figueredo, Elizabeth Valverde Macedo, Jorge Carlos Santos da Costa   +2 more
doaj   +1 more source

Drug Discovery Approaches to Target E3 Ligases

ChemBioChem, Volume 26, Issue 1, January 2, 2025.
Comprehensive review presenting the different drug discovery approaches that until now have been employed in academic and pharmaceutical settings to identify new E3 ligase small molecules ligands and contributing to the expansion of the targeted protein degradation field. Abstract Targeting E3 ligases is a challenging area in drug discovery.
Alejandra Rodríguez‐Gimeno, Carles Galdeano   +1 more
wiley   +1 more source

Pharmacometabolomics Approach to Explore Pharmacokinetic Variation and Clinical Characteristics of a Single Dose of Desvenlafaxine in Healthy Volunteers

Pharmaceutics
This study investigated the effects of a single dose of desvenlafaxine via oral administration on the pharmacokinetic parameters and clinical and laboratory characteristics in healthy volunteers using a pharmacometabolomics approach. In order to optimize
Anne Michelli Reis Silveira, Salvador Sánchez-Vinces, Alex Ap. Rosini Silva, Karen Sánchez-Luquez, Pedro Henrique Dias Garcia, Caroline de Moura Garcia, Rhubia Bethania Socorro Lemos de Brito, Ana Lais Vieira, Lucas Miguel de Carvalho, Marcia Ap. Antonio, Patrícia de Oliveira Carvalho   +10 more
doaj   +1 more source

Endoaesthetic Management of Type II Dens Invaginatus Associated With Root Perforation and Apical Abscess: A Case Report

Case Reports in Dentistry, Volume 2025, Issue 1, 2025.
Dens invaginatus (DI) is a developmental anomaly that affects teeth. This case report demonstrates the successful endoaesthetic management of a Type II DI in the maxillary right lateral incisor (Tooth 12). A 12‐year‐old female patient presented with pain and swelling in Tooth 12, which had previously been diagnosed with DI and accessed endodontically ...
Alessandro Moreira Freire, Orlando Aguirre Guedes, Lara Borges de Deus, Paulo Eduardo Mafra, Gustavo Silva Chaves, Karolina Kellen Matias, Juliano Gonçalves Miguel, Erica Eugênia Javarez Freire, Daniel de Almeida Decurcio, Hannah Wesley   +9 more
wiley   +1 more source