Results 231 to 240 of about 9,808 (274)

Comparison of the haemodynamic and autonomic effects of frusemide and indapamide, and localization of the natriuretic action of indapamide

Current Medical Research and Opinion, 1977
SummaryA series of experiments was carried out to investigate the comparative diuretic and natriuretic effects of indapamide and frusemide in saline loaded dogs, and the effects of indapamide on urinary diluting and concentrating mechanisms. Comparative studies were also conducted on the acute haemodynamic effects of the two drugs in anaesthetized dogs
M. Laubie, H. Schmitt
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The Hypotensive Action of Indapamide

1987
Three main theories have been advanced to explain the antihypertensive action of diuretics. The first two are related to their sodium depleting effects; that is, blood pressure lowering results from a reduction in extracellular fluid volumen or in the water, sodium and calcium content of the arterioles.
Ferrer Ci, J. C. Cornejo, L. I. Juncos
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Pharmacokinetics and metabolism of indapamide: A review

Current Medical Research and Opinion, 1977
The comparative pharmacokinetics and metabolism of indapamide have been studied in the dog, rat and human using 14C-indapamide.
A. R Taylor, D. B Campbell, J. R. B. Williams, Y. W Hopkins   +3 more
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Acute transient myopia induced by indapamide

American Journal of Ophthalmology, 2000
To report on a case of acute transient myopia associated with ciliochoroidal detachment induced by indapamide.Case report. Clinical examination, ultrasonography, and fluorescein angiography were performed during the acute phase of disease and convalescence.After indapamide was discontinued, acute bilateral myopia, which was associated with anterior ...
Alain Gaudric, Ali Erginay, P Y Santiago, Pierre Blain, Pascale Massin, Michel Paques   +5 more
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Binding of indapamide to serum proteins and erythrocytes

Biochemical Pharmacology, 1988
The binding of indapamide to isolated serum proteins and erythrocytes was studied in order to understand its blood distribution. In serum, indapamide was mainly bound to alpha 1-acid glycoprotein with a high affinity (K = 73.4/mM), and to albumin and lipoproteins.
Pascale Riant, B. Coulomb, A. Renouard, Saïk Urien, I. Rocher, Jean-Paul Tillement   +5 more
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Indapamide: Measurement by a Fluorescence Assay

Current Medical Research and Opinion, 1977
SummaryA fluorescence assay for indapamide which is both sensitive and capable of handling large numbers of samples has been developed. Reaction of indapamide with NaOH at 100°C has been shown to yield a fluorescent product, which has excitation and emission wavelengths of 284 nm and 356 nm, respectively.
Martha M. Johnston, L B Mellett, Peter E. Grebow   +2 more
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The Disposition of ¹⁴C‐indapamide in Man

The Journal of Clinical Pharmacology, 1983
Abstract: The metabolism of 14C‐indapamide labeled in the indoline ring was determined after a single oral administration of a solution (4.99 mg, 90.47 μCi) to four fasted adult male volunteers. 14C‐indapamide was rapidly absorbed, and peak blood concentrations of radioactivity occurred by 0.5 hour in three subjects and at 2 hours in one subject.
Lewis J. Klunk, Edward S. Neiss, Samuel Ringel   +2 more
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Semiautomated Assay for Indapamide in Biological Fluids

Journal of Pharmaceutical Sciences, 1981
A sensitive fluorescence procedure for the determination of indapamide in plasma and whole blood was developed. The procedure requires preextraction of the biological sample followed by continuous-flow analysis. The assay is sensitive to indapamide levels of 25 ng/ml in plasma and blood. A linear response from 25 to 200 ng/ml is observed. The procedure
Jo A. Treitman, Anne K. Yeung, Martha M. Johnston, Peter E. Grebowx   +3 more
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Electrochemical oxidation of the diuretic indapamide

Electroanalysis, 1996
AbstractThe electrochemical oxidation of the 3‐(Aminosulfonyl)‐4‐chloro‐N‐(2,3‐dihydro‐2‐methyl‐1H‐indol‐1‐y1)benzamide, Indapamide, was studied in aqueous alcoholic media (9:91 MeOH+H2O, pH range 1–13) and two different ionic media (KNO3 and KCl) at carbon electrodes.
Rosa M. Alonso, Rosa M. Jiménez, María J. Legorburu   +2 more
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Antidiuretic effect of indapamide in central diabetes insipidus

Acta Endocrinologica, 1990
Abstract. Indapamide produced a significant decrease in urinary output in three patients with central diabetes insipidus. The 24-h urinary volume was reduced from 5 to 2.3 1 in a 39-year-old woman; from 11 to 4.3 1 in a 30-year-old man, and from 16 to 9.2 1 in a 40-year-old man receiving 2.5 mg of indapamide per day.
KOCAK, M, KARADEMIR, BM, TETIKER, T
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