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Effects of indapamide on the quality of life of hypertensive patients
The American Journal of Medicine, 1988This study analyzed the variation in the parameters characterizing the quality of life and well-being of hypertensive patients treated with indapamide. Thirty patients (10 men and 20 women; mean age, 52.5 +/- 2.1 years, SEM) were selected after a three-week observation period during which patients received placebo.
Alain Safavian +3 more
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Preparation of Indapamide slow-release pellets
Advances in Therapy, 2004During the process of developing a slow-release formulation of indapamide, researchers created a drug-containing pellet coated with Eudragit RS100 (Rohm GMbH & Co. KG, Darmstadt, Germany) to control the rate at which the drug was released. The two main variables were the agglomerants used in the pellet preparation and the amount of Eudragit RS100 used ...
Mingming Su +4 more
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Pharmacological Properties of Indapamide
Clinical Pharmacokinetics, 1999Indapamide is a thiazide-related diuretic drug with antihypertensive properties. Its blood pressure-lowering action has been repeatedly demonstrated in acute as well as chronic conditions in various genetically and nongenetically determined forms of hypertension. In rats, the maximally effective oral dose is 3 mg/kg/24 h.
Jean Sassard +2 more
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Effect of indapamide on the baroreceptor reflex in essential hypertension
European Journal of Clinical Pharmacology, 1983The effect of chronic treatment with indapamide on blood pressure (BP), baroreceptor sensitivity (BRS) and vascular reactivity (VR) were investigated in 10 patients with essential hypertension. After 3 months of therapy with indapamide 2.5 mg/d the mean arterial pressure (MAP) had decreased from 135 +/- 6 to 112 +/- 2 mmHg (p less than 0.001); the ...
CARRETTA, RENZO +6 more
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Effect of indapamide on phosphate metabolism and vascular reactivity
The American Journal of Medicine, 1988The effect of indapamide, a nonthiazide diuretic, on urinary electrolytes, renal hemodynamics, and tissue inorganic phosphate was examined in normal anesthetized rats, as well as on vascular reactivity in vitro. Intravenous injections of 0.5 ml/kg of 1 x 10(-5), 1 x 10(-4), and 1 x 10(-3) M indapamide solutions reduced mean arterial pressure from 123 ...
Marie-Chantal Lafreniere +3 more
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The possible mode of action of indapamide: a review
Current Medical Research and Opinion, 1983It is not clear whether indapamide reduces blood pressure by a vasodilator or a diuretic action. This review attempts to answer this fundamental question. Cardiovascular studies show small increases in cardiac output, heart rate and stroke volume with a significant reduction in peripheral resistance.
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The place of indapamide in the treatment of arterial hypertension
Current Medical Research and Opinion, 1983Clinical efficacy is not the sole criterion today in the drug treatment of hypertension, a condition which is so often asymptomatic and one which demands prolonged, usually lifetime, management of the patient. Patient compliance with treatment is essential and the practical usefulness of a drug can be determined by its side-effect liability ...
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Indapamide-Induced Severe Hyponatremia and Hypokalemia
Annals of Pharmacotherapy, 1995Objective: To describe 2 patients with severe indapamide-induced hyponatremia and hypokalemia and to discuss the incidence and mechanisms of diuretic-induced hyponatremia and hypokalemia. Case Summary: Two women aged 60 and 62 years presented with severe hyponatremia (plasma sodium concentrations of 103–104 mmol/L) and hypokalemia (plasma potassium ...
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Perindopril/Indapamide-Induced Photosensitivity
Hospital Pharmacy, 2023Chaker Ben Salem +4 more
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Combination perindopril/indapamide for the treatment of hypertension: A review
Expert Opinion on Pharmacotherapy, 2011Hypertension is an important risk factor for cardiovascular complications and the need to treat this condition has been well established. Despite the availability of many antihypertensive drugs, it is often necessary to combine several of these drugs.
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