Results 81 to 90 of about 38,753 (259)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

On the property-denoting clitic ne and the determiner de/di: a comparative analysis of Catalan and Italian

open access: yesLinguistics
The clitic pronoun ne and the functional element de introducing nominal constituents have many nominal and prepositional functions across Romance languages.
Espinal M.Teresa, Giusti Giuliana
doaj   +1 more source

Textual Origins of the Indefinite Article in Swedish

open access: yesfsp, 2013
ABSTRACT The present paper studies the earliest stages of the grammaticalization of indefinite article in Old Swedish. The study is based on a corpus of Old Swedish texts and uses the model of grammaticalization as proposed by Heine 1997.
openaire   +4 more sources

The ecclesiastical fight against storm‐makers in the Latin west

open access: yesEarly Medieval Europe, EarlyView.
This paper studies the strategies used by the Church to fight against the storm‐makers. These figures were said to cause the storms that ruined crops, and during Late Antiquity and the early Middle Ages in the Visigothic and Frankish kingdoms were subject to punishment and constraints.
Juan Antonio Jiménez Sánchez
wiley   +1 more source

The use of the indefinite article with proper nouns in the French language

open access: yesТонкие химические технологии, 2011
The article deals with the use of indefinite article with proper nouns. The role of proper nouns in a sentence is investigated. Three types of interpretation of proper nouns are given.
E. L. Lukomskaya
doaj  

Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)—an arsenic‐based herbicide—in horses in Brazil

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Arsenic poisoning in horses is rarely reported in the literature. However, arsenic compounds can be present in rodenticides, pesticides, and herbicides, representing a potential source of accidental exposure for horses. Objective To describe the epidemiological, clinical, and laboratory findings from a herd of 31 horses exposed to ...
Gabriella Faria Pereira   +7 more
wiley   +1 more source

“I Stayed, Because… I Needed to Have a Plan”: Nigerian Migrant Women's Experiences of Gender‐Based Violence, Resilience and Resistance

open access: yesThe Howard Journal of Crime and Justice, EarlyView.
ABSTRACT This article critiques gendered, cultural and racial stereotypes of Nigerian migrant women as passive victims of intimate partner violence (IPV) in the United Kingdom. Based on 14 semi‐structured interviews, it reveals how spouse visa restrictions limit access to welfare and constrain women's ability to escape abuse.
Yemisi L. Sloane, Aisha K. Gill
wiley   +1 more source

Medical Knowledge Integration Into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

open access: yesInternational Statistical Review, EarlyView.
Summary The goal of precision medicine is to provide individualised treatment at each stage of chronic diseases, a concept formalised by dynamic treatment regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from clinical data to enhance therapeutic effectiveness.
Sophia Yazzourh   +3 more
wiley   +1 more source

Crisis All Around? Crisification of the EU Institutional Discourse: A Longitudinal Perspective (2012–2024)

open access: yesJCMS: Journal of Common Market Studies, EarlyView.
Abstract The increasing frequency and complexity of crises have contributed to the crisification of EU policy‐making and governance. Despite its far‐reaching implications, the discursive dimension of this process remains seriously under‐researched.
Karolína Garančovská   +1 more
wiley   +1 more source

Multiple positive solutions to the fractional Kirchhoff problem with critical indefinite nonlinearities

open access: yesElectronic Journal of Differential Equations, 2020
This article concerns the existence and multiplicity of positive solutions to the fractional Kirchhoff equation with critical indefinite nonlinearities by applying the Nehari manifold approach and fibering maps.
Jie Yang, Haibo Chen, Zhaosheng Feng
doaj  

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