Results 71 to 80 of about 134,477 (247)

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Small, EarlyView.
This article highlights a novel, organic solvent‐free lipid nanoparticle (LNP) formulation that avoids cholesterol, thereby reducing hepatic accumulation and immune activation. These BLNPs enable potent, flexible, and scalable gene delivery, supporting personalized medicine and diverse nucleic acid applications.
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +14 more
wiley   +1 more source

A minimax formula for the principal eigenvalues of Dirichlet problems and its applications

Electronic Journal of Differential Equations, 2007
A minimax formula for the principal eigenvalue of a nonselfadjoint Dirichlet problem was established in [8,18]. In this paper we generalize this formula to the case where an indefinite weight is present.
Tomas Godoy, Jean-Pierre Gossez, Sofia R. Paczka   +2 more
doaj  

On a class of fractional \(p(x,y)-\)Kirchhoff type problems with indefinite weight

Cubo
This paper is concerned with a class of fractional \(p(x,y)-\)Kirchhoff type problems with Dirichlet boundary data along with indefinite weight of the following form \begin{equation*} \left\lbrace\begin{array}{ll} M\left(\int_{Q}\frac{1}{p(x,y)}\frac{|
Seyed Mostafa Sajjadi, Ghasem Alizadeh Afrouzi   +1 more
doaj   +1 more source

Non-real eigenvalues of symmetric Sturm–Liouville problems with indefinite weight functions

Electronic Journal of Qualitative Theory of Differential Equations, 2017
The present paper deals with non-real eigenvalues of regular Sturm–Liouville problems with odd symmetry indefinite weight functions applying the two-parameter method.
Bing Xie, huaqing Sun, Xinwei Guo
doaj   +1 more source

Spectral bounds for singular indefinite Sturm-Liouville operators with $L^1$--potentials [PDF]

, 2017
The spectrum of the singular indefinite Sturm-Liouville operator $$A=\text{\rm sgn}(\cdot)\bigl(-\tfrac{d^2}{dx^2}+q\bigr)$$ with a real potential $q\in L^1(\mathbb R)$ covers the whole real line and, in addition, non-real eigenvalues may appear if the ...
Behrndt, Jussi, Schmitz, Philipp, Trunk, Carsten   +2 more
core   +1 more source

Funding, Facilities, and the Face of Homelessness: Heterogeneous Impacts of Federal Grants on Sheltered and Unsheltered Counts

Southern Economic Journal, EarlyView.
ABSTRACT This paper examines the causal impact of federal homeless‐assistance grants on reported homelessness and shelter capacity across 370 Continuums of Care in 2019. We exploit cross‐sectional variation in pre‐1940 housing shares, used in Community Development Block Grant formula allocations, as an instrument for combined CoC and Emergency ...
Luke Maddock, Anita Alves Pena
wiley   +1 more source

From Nominalisation to Passive in Old Tibetan: Reconstructing Grammatical Meaning in an Extinct Language1

Transactions of the Philological Society, EarlyView.
Abstract Based on an analysis of the Old Literary Tibetan corpus—a corpus of the oldest documented Tibetic language—the present study provides evidence that literary Tibetan v3 verb stems (commonly termed ‘future’) initially encoded passive voice. New arguments put forward in this article range from Trans‐Himalayan nominal morphology to early Tibetan ...
Joanna Bialek
wiley   +1 more source

AGRICULTURE IN A SOCIALIST CITY: Towards an Alter‐Urban Political Ecology

International Journal of Urban and Regional Research, EarlyView.
Abstract Urban political ecology has developed as a critique of capitalist urbanization. This article develops the concept of alter‐urban political ecology to define urban environments emerging not from capitalist urbanization but from efforts to transform it. Drawing on archival research and ethnographic fieldwork in five urban farms in socialist Cuba,
Gustav Cederlöf
wiley   +1 more source

On the existence of positive solutions for an ecological model with indefinite weight

Arab Journal of Mathematical Sciences, 2016
This study concerns the existence of positive solutions for the following nonlinear boundary value problem: {−Δu=am(x)u−bu2−cupup+1−Kin  Ω,u=0on  ∂Ω, where Δu=div(∇u) is the Laplacian of u, while a,b,c,p,K are positive constants with p≥2 and Ω is a ...
Saleh Shakeri, Ghasem A. Afrouzi, Armin Hadjian   +2 more
doaj   +1 more source

Strongly indefinite systems with critical sobolev exponents and weights

Applied Mathematics Letters, 2004
Let \(\Omega\) be a bounded smooth domain in \(\mathbb R^N\), \(N\geq 4\) and \(\lambda,\mu\in\mathbb R\). The author deals with the following problem: \[ -\Delta v=\lambda u+K(x)|u|^{p-1}u\text{ in }\Omega, \quad -\Delta u=\mu v+ Q(x)|v|^{q-1}v\text{ in }\Omega, \quad u=v=0\text{ on }\partial\Omega, \tag{1} \] where \(p,q>1\) and coefficients \(K,Q ...
openaire   +1 more source